Which of the following TWO are true about gamma:delta T cells? [PLEASE CHOOSE TWO ANSWERS] They typically respond to peptides presented by MHC class I They typically respond to peptides presented by MHC class II They are not tested as thoroughly as alpha:beta T cells during development In humans, they do not require MHC presentation of peptides In humans, they are only produced before birth

Which of the following TWO are true about gamma:delta T cells? [PLEASE CHOOSE TWO ANSWERS] They typically respond to peptides presented by MHC class I They typically respond to peptides presented by MHC class II They are not tested as thoroughly as alpha:beta T cells during development In humans, they do not require MHC presentation of peptides In humans, they are only produced before birth

Biology 2e

2nd Edition

ISBN:9781947172517

Author:Matthew Douglas, Jung Choi, Mary Ann Clark

Publisher:Matthew Douglas, Jung Choi, Mary Ann Clark

Chapter42: The Immune System

Section: Chapter Questions

Problem 1VCQ: Figure 42.11 Which of the following statements about T cells is false? Helper T cells release...

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Examine Type IV hypersensitivities by completing each sentence. 54 Туре IV МНС I tuberculin Compared to Type III hypersensitivities, reactions primarily involve -cell activity. T allografts Type IV dysfunction is known as secondary antigen exposure. hypersensitivity for symptoms arise 1 to several days following contact dermatitis delayed One example, infectious allergy, occurs during the reaction in persons sensitized by tuberculosis Lysosome infection. xenografts GVHD which occurs after exposure to antigens in The most common delayed allergic reaction, however, is plant resins, drugs, or personal articles, and involves the production of inflammatory cytokines that cause blistering. Autografts В -mediated reactions, while Finally, host rejection of grafted tissue can occur due to occurs when passenger cells in the grafted tissue attack host cells. MHC II Psoriasis
The following events elicit an antibody response to a T-dependent antigen (Ag). Put them in order and indicate which one would happen third (of the five answers as shown, not necessarily number 3 on a lecture slide or text diagram). O Ag-presenting cell displays Ag fragments next to self (MHC) molecule on its surface Helper T cell (TH) activates an appropriate B cell Helper T cell (TH) specific for the Ag binds to MHC-Ag complex B cell differentiates into a plasma cell; secretes antibodies specific for the Ag Ag-presenting cell phagocytizes Ag-carrying microbe
Peptide editing is an important component of antigen presentation for both MHC class I and MHC class II pathways, as it drives the preferential presentation of high-affinity binding peptides. For MHC class II peptide editing, HLA-DM plays a key role. In the absence of HLA-DM: MHC class II molecules traffic to the cell surface with CLIP in their binding sites. No MHC class II molecules are released to traffic to the cell surface. MHC class II molecules bind to HLA-DO and are inhibited from binding peptides. Pathogens can evade the immune system by blocking peptide exchange on MHC class II. HLA-DO competes for high-affinity binding peptides with MHC class II molecules and blocks antigen presentation.
Which of the following statements is the most accurate concerning lymphocytes? a. T cells and B cells both express TCRs. These are the product of approximately 100 genes. Each lymphocyte expresses only one of the ~100 receptors coded for by these genes, and in the absence of clonal selection the liklihood that two cells express the same receptor is only moderate b. T cells and B cells express TCRs and BCRs respectively. These are the product of genetic recombination and can comprise one of millions of combinations. Each lymphocyte can express 1000s of different receptor variants, maximizing the likelihood that a single adaptive immune cell will recognize pathogen-associated antigens. c. T cells and B cells express TCRs and BCRs respectively. These are the product of genetic recombination and can comprise one of millions of combinations. Each lymphocyte expresses only one of these receptors, and in the absence of clonal selection the liklihood that two cells express the same…
Which of the following statements is correct? B cells only recognize antigen presented on MHC class II Dendritic cells are the only cells that can present antigen via both MHC class I and MHC class II CD8 + T cells recognize antigen presented on MHC class I B cells can present antigen via MHC class II for T cells The B cell receptor is a membrane-bound antibody Isotype switch leads to the B cell's antibodies being able to recognize a new antigen The T cell receptor recognizes peptides bound to MHC Main function of CD8 + T cells
Which of the following statements are NOT TRUE about Antigen Presenting Cells (APCs)? (Select all that apply) An APC can become activated from antigen binding as well as MHC binding APCs can carry mutliple MHCs Antigen presenting is due to APC activation Adaptive, innate, and non-immune cells can be APCs APCs travel to the sites of resident macrophages to recruit effector immune cells An APC that binds via their expressed MHC II will be killed
All of the following statements concerning regulatory T cells (Treg) are correct, EXCEPT: The regulatory cytokines produced by regulatory T cells are IL-12 and TGF-B O Thymocytes that recognize self-antigen in the thymus with a certain affinity become natural (central) regulatory T cells O In the periphery T cells that recognize self-antigen in the presence of TGF-B become induced regulatory T cells O A Treg cell can suppress self-reactive lymphocytes that recognize peptides different from that recognized itself provided that the peptides are derived from the same tissue O A Treg cell can suppress self-reactive lymphocytes that recognize peptides different from that recognized by itself provided that the peptides are presented by the same antigen-presenting cell (APC)
Match the term with its correct description. selection for thymocytes which recognize self MHC molecules elimination of thymocytes which recognize self continued alpha chain rearrangement until a functional TCR is generated process by which autoreactive thymocytes are eliminated in the thymus activation of a T-cell only if the appropriate MHC molecule presents an antigenic peptide ✓Choose... Apoptosis MHC restriction Positive selection Negative selection T-cell receptor editing Choose...
Which of the following apply to MHCII molecules? Found on the surface of all human cellis Found on the surface of red blood cells Function to present (display) antigen for Tc cells None of the above apply O Found on the surface of antigen presenting cells (APCS) OFunction to present (display) antigen for B cells
Discuss the differences between conventional T cell therapy and Chimeric Antigen Receptor (CAR) T cells.
Which of the following statements about neutrophils is correct? They kill pathogens by producing reactive oxygen species. They are cytotoxic cells that can eliminate pathogens by a mechanism called antibody-dependent cell-mediated cytotoxicity. They present antigens on class II MHC molecules. I only II only I and II only II and III only I, II and III The C1 complement protein is activated when it binds to the Fc region of an antigen-bound antibody. complement receptor of an antigen-bound lectin. Fc region of free antibody. complement receptor of free lectin. complement receptor on phagocytes.
Clear my choice Two antibodies, one is IgM and the other is IgG, both can bind to the same epitope. Which of the following is true about them? O a. They have almost same variable regioi and almost same constant region of the heavy chain. O b. They have almost same variable region but different constant region of the heavy chain. O c. They have different variable region and different constant region of the heavy chain. O d. They have different variable region but same constant region of the heavy chain. SLE is a. Cell mediated autoimmune disease.