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- Which of the following citric acid cycle enzymes catalyzes substrate-level phosphorylation? A) isocitrate dehydrogenase B) α-ketoglutarate dehydrogenase C) succinyl CoA synthetase D) succinate dehydrogenase E) malate dehydrogenaseIn a Lineweaver-Burk graph, the lines representing the uninhibited and inhibited enzyme catalyzed reaction meet each other on the x-axis. The type of inhibition which is occurring is: a) competitive b) noncompetitive c) uncompetitive d) allosteric CO2 exerts direct activity upon hemoglobin by: a) blocking oxygen from binding to the heme group b) displacing BPG from the central cavity c) oxidizing Fe+2 to Fe+3 which does not bind oxygen d) forming an N-terminal carbamate which favors the T-state The dominant motif found in hemoglobin and myoglobin is: a) helix-turn-helix b) twisted beta sheet c) beta barrel d) random coil Which of these is an ketohexose? a) fructose b) glucose c) ribose d) erythrose Which of these is a constitutional isomer of d-glucose? a) fructose b) galactose c) l-glucose d) ribose Which of these is an enantiomer of d-glucose? a) d-fructose b) d- galactose c) l-glucose d) d-ribose Which of these is a diastereomer of…Serum blood of a patient with dislipoproteinemia type 1 has milky appearance even in fasting. If serum stays at low temperature (40) for several hours fatty layer appears on its surface. What are the possible causes of these symptoms? To explain this, answer the questions and do the following tasks: a) what compounds of serum must be tested for that patient in biochemical lab? b) write the reaction which does not occur properly in patient’s blood; c) write down the schemes, explaining how the products of the previous reaction are used in adipose tissue and heart in healthy person 2 hours after a meal.
- Glucosamine is a common compound that inhibits hexokinase action (the transfer of a phosphate group to glucose during glycolysis). A) Describe the consequences of glucosamine exposure on cellular respiration. B) Is glucosamine exposure fatal? Why or why not?which of the following glycolytic reactions is an oxidation? a) G3P to 1,3-BPG b) PEP to Pyr c) lactic acid fermentation under anaerobic conditions d) condensation of acetate with OAA e) succinate decarboxylase reactionWhat coenzymes are required for the ββ-oxidation pathway? A) NAD+ and FAD only B) NAD+ and CoASH only C) CoASH only D) FAD and CoASH only E) FAD, NAD+, and CoASH
- What enzyme is inhibited by the group of medications known as statins? a)HMG-CoA synthase b)Aromatase c)Fatty acid synthase d)Cyclooxygenase1- Catalyzes the production of FADH, in the Krebs cycle: a) isocitrate dehydrogenase b) c) fumarasa aconitase d) a-ketoglutarate dehydrogenase e) succinate dehydrogenase 2- In the Krebs cycle (a single cycle) the following are released: a) one molecule of CO, b) three molecules of NADH c) two FADH2 molecule d) two GTP 3- The enzyme that converts citrate to isocitrate is known What: b) isocitrate dehydrogenase a) aconitase citrate synthetase d) citrate lyase e) fumarase c)3-day -old female newborn with a deficiency of mitochondrial carbamoyl phosphate synthetase develops seizures and lapses into a coma. Which of the following changes in blood concentration is the most likely cause?A) Decreased glucoseB) Increased ammoniaC) Increased ketone bodiesD) Increased lactateE) Increased urea
- In the complete b-oxidation of stearic acid (18:0), a) how many moles of acetyl CoA are produced? b) how many times would the fatty acid pass through the fatty acid spiral for complete oxidation? c) what is the total ATP produced in the citric acid cycle? d) how many moles of NADH are produced? e) how many moles of FADH2 are produced? f) how many moles of ATP are produced after all NADH are reoxidized in the respiratory chain? g) how many moles of ATP are produced after all FADH2 are reoxidized in the respiratory chain? h) how many moles of ATP are produced from the complete oxidation of stearic acid?(a) What are the Vmax and Km (including units) for Tigerzyme? b) What are the Vmax and Km (including units) for Tigerzyme in the presenceof the inhibitor Tar Heel? (c) What are the Vmax and Km (including units) for Tigerzyme in the presenceof the inhibitor Blue Devil?37. Which of the following enzymes catalyzes a reaction that produces NADPH needed for lipogenesis? A) Glucose 6-phosphatase B) Glucose 6-phosphate dehydrogenase C) Glyceraldehyde 3-phosphate dehydrogenase D) Malate dehydrogenase E) Pyruvate dehydrogenase