What would be the individual lifetime cancer risk for an adult male residential consumer

Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
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Suppose a city’s water supply has 0.2 ppb (1ppb=10-3 mg/L) of polychlorinated biphenyls (PCBs) in it. Using the PCB oral slope factor (7.7 (mg/kg-d)-1 and the EPA recommended exposure factors given in Table 6.14 below, (a) What would be the individual lifetime cancer risk for an adult male residential consumer?(b) In a city of 1 million people, use this risk assessment to estimate the number of extra cancers per year caused by the PCBs in the water supply. “Extra” cancers refers to cancers caused by PCBs (as opposed to other causes such as smoking, etc.)(c) Assume the average cancer death rate in the United States in 193 per 100,000 per year. How many cancer deaths would be expected in a city of 1 million? Do you think the incremental cancers caused by PCBs in the drinking water would be detectable?

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