What would be the best base to use toconduct a Claisen Condensation reactionwith the following ester?Sodium PropoxideSodium HydroxideSodium EthoxideSodium Methoxide

In Claisen condensation, strong bases such as hydroxides are not used due to the possibility of…

Answered: What would be the best base to use to…

Organic Chemistry

8th Edition

ISBN:9781305580350

Author:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote

Publisher:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote

Chapter23: Amines

Section: Chapter Questions

Problem 23.29P

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Crossed Claisen condensation reactions require: 1) Two esters where only one can form an enolate anion. 2) Two esters where both can form enolate anions. 3) Two esters where neither can form an enolate anion. 4) The ability to undergo intramolecular reactions. O 1 O 2 4
Carbonyl compounds can be protonated on the carbonyl oxygen. Protonation of the carbonyl oxygen gives a species whose positive charge is delocalized by resonance. Explain why acetic acid (ethanoic acid) is more readily protonated than acetone (propanone).
Draw structures for the carbonyl electrophile and enolate nucleophile.
How would you prepare this nitrile from benzene using a diazonium salt? benzene →
Draw the reaction of the Grignard reagent interacting water and the product produced. bromobenzene Br MgBr Mg ether HCI phenyl magnesium bromide (Grignard reagent) OH off triphenyl methanol
Draw a stepwise mechanism for the following reaction. This reaction combines two processes: the opening of an epoxide ring with a nucleophile and the addition of an electrophile to a carbon–carbon double bond. (Hint: Begin the mechanism by protonating the epoxide ring.)
Why is it not advisable to use aqueous hydrochloric acid in a Grignard reaction of a ketone? A) The Grignard reagent will react with the acid and cannot react with the ketone. B) The ketone will be protonated and will become unreactive. C) The ketone will form an unreactive enol. D) The Grignard reagent won't dissolve in aqueous solutions
What products will be obtained if the following compound is hydrolyzed completely in an aqueous solution of HCL?
Draw the major product for the following reaction: ? 1) Disiamylborane 2) H₂O₂, NaOH Draw Your Solution
A powerful reducing agent that can reduce all carbonyl groups Sodium borohydride Lithium borohydride Sodium aluminum hydride Lithium aluminum hydride
In the following reaction mechanism, what best describes the role of the Grignard reagent? + CH₂MgBr 1) ether 2) H3O+ The Grignard reagent acts as a nucleophile and attacks the carbonyl carbon. The Grignard reagent acts as an electrophile and is attacked by the oxygen. The Grignard reagent is first protonated by the acid. The Grignard reagent acts as a nucleophile and removes a proton from the methyl group attached to the carbonyl carbon.
Draw the most stable enol form for this structure

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What would be the best base to use to conduct a Claisen Condensation reaction with the following ester? Sodium Propoxide Sodium Hydroxide Sodium Ethoxide Sodium Methoxide