Answered: We are planning a clinical trial to…

Name: We are planning a clinical trial to compare a new compound designed to
Uploaded: 2024-03-20T07:07:37.000Z
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Description: We are planning a clinical trial to compare a new compound designed to improve wound healing in trauma patients to a placebo. Based on previous studies we expect about 58% of the patients taking the new compound to have substantial reduction in the s

MATLAB: An Introduction with Applications

6th Edition

ISBN:9781119256830

Author:Amos Gilat

Publisher:Amos Gilat

Chapter1: Starting With Matlab

Section: Chapter Questions

Problem 1P

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We are planning a clinical trial to compare a new compound designed to improve wound healing in trauma patients to a placebo. Based on previous studies we expect about 58% of the patients taking the new compound to have substantial reduction in the size of their wound as compared to 44% in the placebo group. how many subjects per group would be required to detect the difference in proportions observed in the trial with 80% power? A two-sided test is planned at alpha = 0.05

Expert Solution

Step 1

From the provided information,

p₁ = 0.58, p₂ = 0.44

The level of significance (α) = 0.05

β = 0.80

The pooled proportion can be obtained as:

Step 2

The effect size can be obtained as:

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