Vasopressin or antidiuretic hormone (ADH) is a peptide hormone synthesized in thea)hypothalamus. This hormone, when present, induces expression of water transport proteins(aquaporins) in the late distal tubule and collecting duct of the kidney to increase waterreabsorption. Binding to the receptor triggers an intracellular cyclic adenosinemonophosphate (CAMP) pathway.Arrange the following steps of hormone signalling in the proper order by putting 1, 2, 3, etcin the space provided,CAMP activates CAMP-dependent protein kinase (PKA).Recruitment of inactive G-protein made of heterotrimeric subunits which hasGDP bound to a-subunit.Conformation change in GPCR.Adenylyl cyclase converts ATP into CAMP.PKA phosphorylates proteins in the cell.A cellular response is seen in the cell.a-subunit with GTP bound activates adenylyl cyclase.Activation of G-protein, thus GDP released an GTP binds to a-subunit.a-subunit of G-protein dissociates from By-dimer.Hormone binding to its G-protein coupled receptor (GPCR).Increase in CAMP concentration, which is the second messenger.

Cyclic AMP is a cyclic nucleotide that is chemically known as 3'5'adenosine phosphate. It is…

Answered: Vasopressin or antidiuretic hormone…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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Arrange following the boxed information in sequence regarding the dissociation and reassociation of G proteins following the activation of a G protein coupled receptor. GTP-bound Ga, dissociates from B and y cuhunits Gas exchanges GTP for GDP Gas reassociates with By subunits and the rorentor reforms Binding of the ligand to a G-protein rounled recentor GTP-bound Gas binds and activates adenvlul rurlase GTP is hydrolyzed and GDP bound Gas suhunit dissoriates Conformational change Increased synthesis of CAMP from ATP
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Endocrine Glands and Their Hormones- Assignment Еxample Organs/gland Hormone Site of Action Target Interactions Synthesis Hypothalamus Hypothalamus GHRH Stimulates Somatotrophs Antagonistic release of in the with GHIH hGH Anterior pituitary Adrenal Gland Aldosterone Zona Principal cells Antagonistic Retain Na+, (mineralocorticoids) | glomerulosa of excretes K+ in Kidney with atrial adrenal cortex and H+ natriuretic peptide (ANP) Pancreas Insulin Beta cells of Lowers All body cells Antagonistic with Glucagon pancreas blood glucose levels

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