Using three examples, describe how allosteric sites are important in the function of genetic regulatory proteins.

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
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Using three examples, describe how allosteric sites are important in the function of genetic regulatory proteins.

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Step 1

Enzymes are proteinaceous catalysts that are genetically encoded by the cell often present with non-protein cofactors. Enzymes and substrates bind by the "induced fit" technique, followed by slight conformational modifications upon substrate contact, causing binding to the active site of the protein. This change in the shape of the enzyme allows rapid binding of potential substrates incorrect orientation ion the active site

Step 2

Allostery is described as the process of modulating the activity of a protein at a site other than the active site called an allosteric center. The particular expression of a gene is achieved through the interaction and binding of protein transcription factors to unique DNA sequence domains found in the regulatory region of the gene usually distinct from the coding region.

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