used in commercial sunscreens. Predict the missing reagents and/or products needed to complete the following synthesis of PABA. HN 1. KMnO4, H₂O, heat 2. H* workup) HO O NH2NH2, KOH heat CH3C(O)CI AICI 3 H3Q+ ⒸO-NO Sn HCI SH Select to Edit HOO
Reactions of Ethers
Ethers (R-O-R’) are compounds formed by replacing hydrogen atoms of an alcohol (R-OH compound) or a phenol (C6H5OH) by an aryl/ acyl group (functional group after removing single hydrogen from an aromatic ring). In this section, reaction, preparation and behavior of ethers are discussed in the context of organic chemistry.
Epoxides
Epoxides are a special class of cyclic ethers which are an important functional group in organic chemistry and generate reactive centers due to their unusual high reactivity. Due to their high reactivity, epoxides are considered to be toxic and mutagenic.
Williamson Ether Synthesis
An organic reaction in which an organohalide and a deprotonated alcohol forms ether is known as Williamson ether synthesis. Alexander Williamson developed the Williamson ether synthesis in 1850. The formation of ether in this synthesis is an SN2 reaction.
![para-Aminobenzoic
acid (PABA) is
used in commercial sunscreens.
Predict the missing reagents and/or
products needed to complete the
following synthesis of PABA.
HN
O
! 1. KMnO4,
H₂O, heat
2. H*
(workup)
HO
8
HN,
NH2NH2, KOH
heat
CH3C(O)CI
AICI 3
H3O+
Sn
HCI
SH
Select to Edit
OH
Select to Edit
A
B
D
E
HNO3
=
cat. H₂SO4
Br2
의
FeBr3
NH2NH2, KOH
heat
NaNO2
==
H₂SO4
H₂O
HCI](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2Fcce22567-888a-4fc7-8d95-6bafc98f7fb0%2F1f85d4a5-e644-46f8-9e7c-222093badb16%2Fivsbt6_processed.jpeg&w=3840&q=75)
![para-Aminobenzoic
acid (PABA) is
used in commercial sunscreens.
Predict the missing reagents and/or
products needed to complete the
following synthesis of PABA.
HN,
! 1. KMnO4,
! H₂O, heat
O
2. H*
(workup)
HO.
HN
NH2NH2,
KOH
heat
CH3C(O)CI
AICI3
H3O+
ⒸO-NⓇ
Sn
HCI
SH
Select to Edit
OH
Select to Edit
A
B
с
D
E
CH3CO2H
AICI 3
CH3C(O)CI
3
AICI 3
CH3CH2C(O)CI
CH3CH2CI
AICI 3
CH3C(O)CI](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2Fcce22567-888a-4fc7-8d95-6bafc98f7fb0%2F1f85d4a5-e644-46f8-9e7c-222093badb16%2F0xkfrvd_processed.jpeg&w=3840&q=75)
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