Microtubules carrying GDP at their ends are more likely to lose tubu-lin monomers. Show how these facts can explain the remarkableobservation that at certain GTP levels some microtubules in a mixturewill grow while others simultaneously shrink. Tubulin binds GTP, and the polymerization of a microtubule is greatlystimulated when a tubulin molecule at the growing end carries GTP.Tubulin also has a GTPase activity, with a low-turnover number.

Microtubules are made up of protein tubulins that can undergo quick growth or dissolution by…

Answered: Microtubules carrying GDP at their ends…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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Similar questions

What effect does binding of the IRF protein to the IRE in the mRNA encoding ferritin have on the production of ferritin? Briefly explain why this effect is observed.
Under what conditions might one expect a deficiency of hypoxan- thine-guanine phosphoribosyltransferase to affect the rate of pyrimidine nucleotide biosynthesis? How might one estimate the rate of pyrimidine nucleotide biosynthesis in living animals or people?
Intramitochondrial ATP concentrations are about 5 mM, and phos- phate concentration is about 10 mM. If ADP is five times more abundant than AMP, calculate the molar concentrations of ADP and AMP at an energy charge of 0.85. Calculate AG for ATP hydrolysis at 37 °C under these conditions. The energy charge is the concentra- tion of ATP plus half the concentration of ADP divided by the total adenine nucleotide concentration: [ATP] + 1/2[ADP] [ATP] + [ADP] + [AMP]
Genetic testing of a 29-month-old boy shows a mutation in the Phe residue at position 508 in the cystic fibrosis transmembrane conductance regulator (CFTCR) gene. Cultured skin fibroblasts from the boy contain an abnormal form of CFTCR protein bound to ubiquitin. Which of the following structures is the most likely site of elimination of these abnormal proteins in this patient? A) Endoplasmic reticulum B) Endosome C) Golgi complex D) Lysosome E) Proteasome
8) A Leu > Ala mutation at a site buried in the core of the enzyme lysozyme ends up being destabilizing. Explain why in terms of AH", AS" (for both the protein and solvent), and AG".
Microtubules in an animal cell: O a. undergo assembly if the concentration of GTP-bound tubulin dimers is high and a cell is exposed to vinblastine O b. undergo disassembly if the concentration of GDP-bound tubulin dimers is high and a cell is exposed to taxol O c. undergo disassembly if the concentration of GTP-bound tubulin dimers is high and a cell is exposed to colchicine O d. undergo assembly if the concentration of GTP-bound tubulin dimers is high and a cell is exposed to colchicine
PfCRT is found to have 10 peaks on a hydropathy plot given its primary sequence. Researchers also noted that each peak is comprised of about 30 amino acids. The digestive vacuole membrane is 45Å in Plasmodium species. Explain why researchers conclude there are 10 transmembrane helices from these two pieces of data.
Propose an experimental strategy to characterize the sequence and linkages of different glycan subtypes that comprise the glycome. For example, how might protein-associated N- and O-glycans be structurally characterized?
Specificity in fusion between vesicles involves two discrete and sequential processes. Describe the first of the two processes and its regulation by GTPase switch proteins. What effect on the size of early endosomes might result from overexpression of a mutant form of Rab5 that is stuck in the GTP-bound state?
You are studying how your Lys-Val-Thr tripep de interacts with another pep de, which places an Asp in close proximity to the Lys on your pep de. How would the presence of an Asp side chain affect the pKa of the Lys side chain? Briefly explain your reasoning. (remember pKas are rela ve, pKa=log([H+][A-]/[HA])
What is the pelleting time for eukaryotic ribosome subunits, 40S and 60S, in a rotor with k = 180? Assume that the medium viscosity and density are similar to water at %3D 20°C.
1 2 Glycogenin is a homodimer of 37 kDa subunits. (Homodimer means identical subunits of type a that form a dimer of type a2). Glycogenin has a chain of a(1,4)-linked units of glucose attached to the sidechain of a tyrosine residue. The chain of a(1,4)-linked glucose units is a primer for the initiation of glycogen synthesis by glycogen synthase. Assume the dimer is stable and not in equilibrium with monomer subunits. Which of the answers below are plausible pathways for attaching or building the primer chain of glucose units? The branching enzyme attaches a chain of 7 glucose units to the tyrosine sidechain of glycogenin. 0 0 0 0 000 The transferase attaches 3 units of a(1,4)-linked glucose to the tyrosine sidechain of glycogenin. Glycogen synthase then extends the chain using UDP-Glc. 0 One glycogenin dimer builds the a(1,4)-llinked glucose chain on a subunit of another glycogenin dimer. -D-O Each subunit builds the a(1,4)-Ilinked glucose chain on the other subunit of the same dimer.…

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