Tristan da Cunha is a group of small islands in themiddle of the Atlantic Ocean. In 1814, a group of 15British colonists founded a settlement on these islands.In 1885, 15 of the 19 males on the island were lost ina shipwreck. In the late 1960s, four cases of retinitispigmentosa, which progressively leads to blindness,were found among the 240 descendants of these settlers remaining on the island. The frequency of retinitis pigmentosa in Britain is about 1 in 6000. Explainthe high incidence of this disease on Tristan daCunha relative to that seen in Britain.

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