trial to assess the association between regular usage of asthma medication prior to turning 18 years old, and height at age 18 years. As per the authors, England Journal reports "From December 1993 through September 1995,we randomly assigned 1041 children between the ages of 5 and 13 years with mild-to-moderate asthma to one of three study groups in the double-blind, placebo-controlled CAMP trial." (reference: Kelly H, et al. Effect of Inhaled Glucocorticoids in Childhood on Adult Height. New England of Medicine (2012). 367 (10)) The random assignment groups were Budesonide, Nedocromil and placebo. The following graphic shows the distribution of female and male participant heights at different times in the study follow-up, presented for the Budesonide and placebo samples. A Unadjusted Height Distribution 200- Budesonide O Placebo 190- 180- 170- 160- 150- 140- 130- 120- 110- 100- 0- Trial entry 2 Yr Trial end Adult Trial entry 2 Yr Trial end Adult Females Males

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A 2012 article in the New England Journal reports the results of a randomized trial to assess the association between
regular usage of asthma medication prior to turning 18 years old, and height at age 18 years. As per the authors,
"From December 1993 through September 1995,we randomly assigned 1041 children between the ages of 5 and 13 years
with mild-to-moderate asthma to one of three study groups in the double-blind, placebo-controlled CAMP trial."
(reference: Kelly H, et al. Effect of Inhaled Glucocorticoids in Childhood on Adult Height. New England of Medicine (2012).
367 (10))
The random assignment groups were Budesonide, Nedocromil and placebo. The following graphic shows the distribution
of female and male participant heights at different times in the study follow-up, presented for the Budesonide and
placebo samples.
A Unadjusted Height Distribution
200-
Budesonide
Placebo
190-
180-
170-
160-
150-
140-
130-
120-
110-
100-
Trial entry
2 Yr
Trial end
Adult
Trial entry
2 Yr
Trial end
Adult
Females
Males
Height (cm)
Transcribed Image Text:A 2012 article in the New England Journal reports the results of a randomized trial to assess the association between regular usage of asthma medication prior to turning 18 years old, and height at age 18 years. As per the authors, "From December 1993 through September 1995,we randomly assigned 1041 children between the ages of 5 and 13 years with mild-to-moderate asthma to one of three study groups in the double-blind, placebo-controlled CAMP trial." (reference: Kelly H, et al. Effect of Inhaled Glucocorticoids in Childhood on Adult Height. New England of Medicine (2012). 367 (10)) The random assignment groups were Budesonide, Nedocromil and placebo. The following graphic shows the distribution of female and male participant heights at different times in the study follow-up, presented for the Budesonide and placebo samples. A Unadjusted Height Distribution 200- Budesonide Placebo 190- 180- 170- 160- 150- 140- 130- 120- 110- 100- Trial entry 2 Yr Trial end Adult Trial entry 2 Yr Trial end Adult Females Males Height (cm)
What is the likely reason that the height distributions for the Budesonide and Placebo groups are similar at "Trial
entry" (time of randomization) for both males and females?
Budesonide is not associated with growth in subjects with asthma.
Subjects were randomized to the Budesonide and placebo groups.
Subjects chose whether to enroll in the Budesonide or placebo groups.
This is just a coincidence.
Transcribed Image Text:What is the likely reason that the height distributions for the Budesonide and Placebo groups are similar at "Trial entry" (time of randomization) for both males and females? Budesonide is not associated with growth in subjects with asthma. Subjects were randomized to the Budesonide and placebo groups. Subjects chose whether to enroll in the Budesonide or placebo groups. This is just a coincidence.
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