September 1995, we randomly assigned 104 asthma to one of three study groups in the of Inhaled Glucocorticoids in Childhood on A

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A 2012 article in the New England Journal reports the results of a randomized trial to assess the association
between regular usage of asthma medication prior to turning 18 years old, and height at age 18 years. As per the
authors,
"From December 1993 through September 1995, we randomly assigned 1041 children between the ages of 5 and
13 years with mild-to-moderate asthma to one of three study groups in the double-blind, placebo-controlled
CAMP trial."
(reference: Kelly H, et al. Effect of Inhaled Glucocorticoids in Childhood on Adult Height. New England of Medicine
(2012). 367 (10))
The random assignment groups were Budesonide, Nedocromil and placebo. The following graphic shows the
distribution of female and male participant heights at different times in the study follow-up, presented for the
Budesonide and placebo samples.
A Unadjusted Height Distribution
200
I Budesonide I Placebo
190
180-
170-
160-
150-
140-
130-
120-
110-
100-
0-
Trial entry
2 Yr
Trial end
Adult
Trial entry
2 Yr
Trial end
Adult
Females
Males
Which of the following statements best summarizes the resulting height distributions for females in the
Budesonide and placebo groups as adults (using only the information in the graphic)?
While there is substantial crossover in the height distributions, the 25, 50, and 75th percentiles were lower
in the Budesonide group when compared to same percentiles in the placebo group.
O Most women (= 75%) in the Budesonide group were shorter than the 25th percentile of height for women in
the placebo group.
Both height distributions are extremely left skewed.
The two height distributions are substantially different.
Height (cm)
Transcribed Image Text:A 2012 article in the New England Journal reports the results of a randomized trial to assess the association between regular usage of asthma medication prior to turning 18 years old, and height at age 18 years. As per the authors, "From December 1993 through September 1995, we randomly assigned 1041 children between the ages of 5 and 13 years with mild-to-moderate asthma to one of three study groups in the double-blind, placebo-controlled CAMP trial." (reference: Kelly H, et al. Effect of Inhaled Glucocorticoids in Childhood on Adult Height. New England of Medicine (2012). 367 (10)) The random assignment groups were Budesonide, Nedocromil and placebo. The following graphic shows the distribution of female and male participant heights at different times in the study follow-up, presented for the Budesonide and placebo samples. A Unadjusted Height Distribution 200 I Budesonide I Placebo 190 180- 170- 160- 150- 140- 130- 120- 110- 100- 0- Trial entry 2 Yr Trial end Adult Trial entry 2 Yr Trial end Adult Females Males Which of the following statements best summarizes the resulting height distributions for females in the Budesonide and placebo groups as adults (using only the information in the graphic)? While there is substantial crossover in the height distributions, the 25, 50, and 75th percentiles were lower in the Budesonide group when compared to same percentiles in the placebo group. O Most women (= 75%) in the Budesonide group were shorter than the 25th percentile of height for women in the placebo group. Both height distributions are extremely left skewed. The two height distributions are substantially different. Height (cm)
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