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To the right is a Michaelis-Menten plot for a wildtype enzyme (STCS) and three different mutants. The substrate is OAS. The mutants have a methionine (M) changed to alanine (A)-three different methionine resudes were mutated. A 12아 90 a. What is the Ka for SIM92A? e SICS O SIM92A a SIM96A a SIM120A 60 b. What is the Vmax for StM92A? 30 c. Which enzyme has the highest kan?

To the right is a Michaelis-Menten plot for a wildtype enzyme (STCS) and three different mutants. The substrate is OAS. The mutants have a methionine (M) changed to alanine (A)-three different methionine resudes were mutated. A 12아 90 a. What is the Ka for SIM92A? e SICS O SIM92A a SIM96A a SIM120A 60 b. What is the Vmax for StM92A? 30 c. Which enzyme has the highest kan?

Chemistry
Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
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Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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1. To the right is a Michaelis-Menten plot for a wildtype enzyme (SECS) and three different mutants. The substrate is OAS. The mutants have a methionine (M) changed to alanine (A)-three different methionine resudes were mutated. A 120 90 a. What is the KM for StM92A? b. What is the Vmax for StM92A? c. Which enzyme has the highest kar?. e SICS O SIM92A E SIM96A a SEM120A 60 30 d. What is the Vmax for StCS?. (OAS) (mM) e. What is the KM for StM92A?, f. Is StCs or STM92A more efficient? (show your work below) t ed bilueb 2. Shown below is a reaction catalyzed by "HA". a. What amino acid could serve as the "HA" in this reaction? Why did you choose this amino acid? b. Draw the energy diagram for the catalyzed and uncatalyzed reaction for this enzyme (assume there is only this one step to this reaction). HA Activity Mal min)
Transcribed Image Text:1. To the right is a Michaelis-Menten plot for a wildtype enzyme (SECS) and three different mutants. The substrate is OAS. The mutants have a methionine (M) changed to alanine (A)-three different methionine resudes were mutated. A 120 90 a. What is the KM for StM92A? b. What is the Vmax for StM92A? c. Which enzyme has the highest kar?. e SICS O SIM92A E SIM96A a SEM120A 60 30 d. What is the Vmax for StCS?. (OAS) (mM) e. What is the KM for StM92A?, f. Is StCs or STM92A more efficient? (show your work below) t ed bilueb 2. Shown below is a reaction catalyzed by "HA". a. What amino acid could serve as the "HA" in this reaction? Why did you choose this amino acid? b. Draw the energy diagram for the catalyzed and uncatalyzed reaction for this enzyme (assume there is only this one step to this reaction). HA Activity Mal min)
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