There are almost 500 naturally occurring variants of hemoglobin. Most are the result of a single amino acid substitution in a globin polypeptide chain. Some variants produce clinical illness, though not all variants have deleterious effects. A brief sample follows. HbS (sickle-cell Hb): substitutes a Val for a Glu on the surface Hb Cowtown: eliminates an ion pair involved in T-state stabilization Hb Memphis: substitutes one uncharged polar residue for another of similar size on the surface Hb Bibba: substitutes a Pro for a Leu involved in an _helix Hb Milwaukee: substitutes a Glu for a Val Hb Providence: substitutes an Asn for a Lys that normally projects into the central cavity of the tetramer Hb Philly: substitutes a Phe for a Tyr, disrupting hydrogen bonding at the alßl1 interface Explain your choices for each of the following: (a) The Hb variant least likely to cause pathological symptoms. (b) The variant(s) most likely to show pl values different from that of HbA. (c) The variant(s) most likely to show a decrease in BPG binding and an increase in the overall affinity of the hemoglobin for oxygen.
There are almost 500 naturally occurring variants of hemoglobin. Most are the result of a single amino acid substitution in a globin polypeptide chain. Some variants produce clinical illness, though not all variants have deleterious effects. A brief sample follows. HbS (sickle-cell Hb): substitutes a Val for a Glu on the surface Hb Cowtown: eliminates an ion pair involved in T-state stabilization Hb Memphis: substitutes one uncharged polar residue for another of similar size on the surface Hb Bibba: substitutes a Pro for a Leu involved in an _helix Hb Milwaukee: substitutes a Glu for a Val Hb Providence: substitutes an Asn for a Lys that normally projects into the central cavity of the tetramer Hb Philly: substitutes a Phe for a Tyr, disrupting hydrogen bonding at the alßl1 interface Explain your choices for each of the following: (a) The Hb variant least likely to cause pathological symptoms. (b) The variant(s) most likely to show pl values different from that of HbA. (c) The variant(s) most likely to show a decrease in BPG binding and an increase in the overall affinity of the hemoglobin for oxygen.
Human Physiology: From Cells to Systems (MindTap Course List)
9th Edition
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Author:Lauralee Sherwood
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Chapter12: Body Defenses
Section: Chapter Questions
Problem 1SQE
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![There are almost 500 naturally occurring variants of hemoglobin. Most are the result of a
single amino acid substitution in a globin polypeptide chain. Some variants produce
clinical illness, though not all variants have deleterious effects. A brief sample follows.
HbS (sickle-cell Hb): substitutes a Val for a Glu on the surface
Hb Cowtown: eliminates an ion pair involved in T-state stabilization
Hb Memphis: substitutes one uncharged polar residue for another of similar size on the
surface
Hb Bibba: substitutes a Pro for a Leu involved in an _ helix
Hb Milwaukee: substitutes a Glu for a Val
Hb Providence: substitutes an Asn for a Lys that normally projects into the central
cavity of the tetramer
Hb Philly: substitutes a Phe for a Tyr, disrupting hydrogen bonding at the alß1 interface
Explain your choices for each of the following:
(a) The Hb variant least likely to cause pathological symptoms.
(b) The variant(s) most likely to show pI values different from that of HbA.
(c) The variant(s) most likely to show a decrease in BPG binding and an increase in the overall
affinity of the hemoglobin for oxygen.](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2F396c29a7-1932-44af-8941-42a2a26dbb50%2F7e3d18e4-9182-4f2b-bc8d-a7ef8acded58%2Fgfe0ti9_processed.jpeg&w=3840&q=75)
Transcribed Image Text:There are almost 500 naturally occurring variants of hemoglobin. Most are the result of a
single amino acid substitution in a globin polypeptide chain. Some variants produce
clinical illness, though not all variants have deleterious effects. A brief sample follows.
HbS (sickle-cell Hb): substitutes a Val for a Glu on the surface
Hb Cowtown: eliminates an ion pair involved in T-state stabilization
Hb Memphis: substitutes one uncharged polar residue for another of similar size on the
surface
Hb Bibba: substitutes a Pro for a Leu involved in an _ helix
Hb Milwaukee: substitutes a Glu for a Val
Hb Providence: substitutes an Asn for a Lys that normally projects into the central
cavity of the tetramer
Hb Philly: substitutes a Phe for a Tyr, disrupting hydrogen bonding at the alß1 interface
Explain your choices for each of the following:
(a) The Hb variant least likely to cause pathological symptoms.
(b) The variant(s) most likely to show pI values different from that of HbA.
(c) The variant(s) most likely to show a decrease in BPG binding and an increase in the overall
affinity of the hemoglobin for oxygen.
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