The total amount excreted into urine as unchanged drug after an oral tablet (A) of 50 mg was 36.4 mg. After an oral capsule dose (B) of 25 mg the U" was 20.3 mg. Calculate the relative bioavailability of the tablet A with respect to capsule B. If the absolute bioavailability of the oral capsule is determined to be 0.86 calculate the absolute bioavailability of the tablet dosage form. You are required to list the given data, formula and steps for calculations 5.1

The total amount excreted into urine as unchanged drug after an oral tablet (A) of 50 mg was 36.4 mg. After an oral capsule dose (B) of 25 mg the U" was 20.3 mg. Calculate the relative bioavailability of the tablet A with respect to capsule B. If the absolute bioavailability of the oral capsule is determined to be 0.86 calculate the absolute bioavailability of the tablet dosage form. You are required to list the given data, formula and steps for calculations 5.1

Chemistry

10th Edition

ISBN:9781305957404

Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Chapter1: Chemical Foundations

Section: Chapter Questions

Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...

See similar textbooks

Similar questions

What would be a good title for the data table below?
1. A wastewater sample has the following composition: NO3 = 37 mg/L as N CO3²-2.5 x 10 mol/L PO4³ = 10 meq/L Ca²+ = 75 mg/L as CaCO3(s) Express each of the above concentrations in mg/L, mol/L, meq (of charge)/L, and ppm. Make and list any necessary assumptions. Show your work and summarize the results in a table.
C7H21O4NHCl(aq) + NaOH(aq) ---> C17H21O4N(aq) + H2O (l) + NaCl(aq) When a 25mL of aqueous solution that contains 62.50g of the salt is treated with NaOH, the salt is converted to pure cocaine. How much water in litres is needed additionally to dissolve the formed pure cocaine?
Transfer 0.5 mL phenolphthalein to a flask 25 mL KHP. Then transfer 13.2mL NaOH in the KHP that make it be pink. As the picture shows. Now, show a complete calculation for the concentration of the sodium hydroxide solution.
Grams of solute per 100 g H₂O 150 140 130 120 110) 100 90 80 70 50 40 30 10 EHN NaNO3 KNO3 KHÁCH Ka Aleci KCIÓS -Ce₂(508)3 0 0 10 20 30 40 50 60 70 80 90 100 Temperature (°C) Rectangular Snip According to the solubility curve graph above, a solution containing 70 g of NaNO3 at 20°C can be described as- a unsaturated insoluble supersaturated d saturated Time left for this assessment: 53:41
Please don't provide handwritten solution...
You have been asked to prepare 500 ml of solution A: 50 mM sucrose, 10 mM KCI, 30 mM Tris (i.e. a 3-component solution). You have been given three separate stock (concentrated) solutions to use: (a) 0.5M sucrose solution, (b) 0.4 M KCI solution and (c) 0.3M Tris Describe how you would prepare your 500 ml of solution A and indicate how much of the each of the three stock solutions you would need.
Biological studies have found that aqueous solutions containing as little as 28 µg of allicin per milliliter inhibit bacterial growth. Express this amount as the number of moles of allicin per liter of solution. $28~\text{ug/mL}=$ $text{mol/L}$ 20 F3 II F8 F4 F5 F6 F7 F9 F10 F11 F12 & %24 4. 3 5 7 9 { } P E T Y U %3D * CO R %23
5 mL of HCl and 5 mL of CH3COOH solutions are titrated with a pipette in a glass bottle and 150 mL of distilled water is added. The initial conductivity (720) of this diluted mixture is measured and recorded in the table. Then, one ml of M/10 NaOH solution is added and their conductivity is measured and recorded in the table. Find the concentration of HCl and CH3COOH.
A sample may contain any combination of sodium hydroxide, sodium carbonate and sodium bicarbonate with inert matter. A 3.00g sample requires 57.57ml of 0.5N hydrochloric acid to reach phenolphthalein endpoint and a total of 105.4ml of acid was used until the methyl orange endpoint was reached. What is the percentage inerts in the mixture? What is the percentage sodium bicarbonate in the mixture? What is the percentage sodium hydroxide in the mixture? What is the percentage sodium carbonate in the mixture?
Based on the following data, determine the molecular weight of the unknown solute. Note the "initial freezing point" refers to the freezing point of the solvent as a pure substance while the "final freezing point" refers to the freezing point of the mixture. Mass Solvent: 15.000 g FPD Constant of Solvent: 4.9 Mass Solute 2.350 g Initial Freezing Point: 85.3oC Final Freezing Point: 82.4oC Your answer should follow the format: a) ΔT b) Molality of the Solution c) mols of solute d) Molecular weight of Solute
In order to avoid the possibility of 2-hour delays this winter, EKU will be stockpiling de-icing salts to help keep the roads and sidewalks clear. Facility Services has been quoted the following prices: K2SO4: $5.35/kg MgSO4: $4.55/kg Which salt provides a better value? Support your answer with a calculation.