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The synthesis of phosphocreatine is unfavorable. If dur- ing extended periods of rest, e.g., sleeping at night, what must be the ADP/ATP ratio if the resting level of PCr/Cr is 30/1?

The synthesis of phosphocreatine is unfavorable. If dur- ing extended periods of rest, e.g., sleeping at night, what must be the ADP/ATP ratio if the resting level of PCr/Cr is 30/1?

Biochemistry
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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(b) The treatment given to the patient was 10 mg of menadione (formula on the right) every 6 hr with a dose of 1 g of ascorbate (Vitamin C) every 6 hr. The rationale for this treatment was that menadione (also called Vitamin K3) could accept electrons from reduced CoQ of the electron transport chain, shuttle them to reduce ascorbate, which, in turn, could reduce cytochrome c(Fe3*) to cytochrome c(Fe2*) that in turn becomes the substrate of Complex IV or cytochrome c oxidase. This artificial sys- tem would bypass the defective Complex III site in the electron transfer chain. To show the effect of this regimen with respect to the ADP phos- phorylative capacity of her skeletal muscle, corresponding 31P NMR spectra are shown on the right. „CH3 2-methyl-1,4-naphthoquinone (menadione)
Transcribed Image Text:(b) The treatment given to the patient was 10 mg of menadione (formula on the right) every 6 hr with a dose of 1 g of ascorbate (Vitamin C) every 6 hr. The rationale for this treatment was that menadione (also called Vitamin K3) could accept electrons from reduced CoQ of the electron transport chain, shuttle them to reduce ascorbate, which, in turn, could reduce cytochrome c(Fe3*) to cytochrome c(Fe2*) that in turn becomes the substrate of Complex IV or cytochrome c oxidase. This artificial sys- tem would bypass the defective Complex III site in the electron transfer chain. To show the effect of this regimen with respect to the ADP phos- phorylative capacity of her skeletal muscle, corresponding 31P NMR spectra are shown on the right. „CH3 2-methyl-1,4-naphthoquinone (menadione)
(a) the left shows a 31P NMR spectrum of the arm of a control female subject at rest, and the diagram on the right the changes measured in the creatine and phosphocreatine levels of the arm at rest and exercise. To illustrate how the ADP phosphorylative capacity was measured, the diagram below on PCr 10L Exer -cise Еxer Rest cise Rest PCr/Pi = 9 PCr CATP YATP ВАТР Pi SP of 20 25 10 15 20 15 5 10 15 ppm Time(min) 31P NMR spectrum of the arm of a control sub- ject at rest showing characteristic resonance features for the phosphate residues of ATP, phosphocreatine (PCr), and Pi. At rest the PCr/Pi ratio is ordinarily - 8-9. Isokinetic ergometer exercise of the control female subject showing intervals of rest and exercise. To obtain this graph, a 3'P NMR spectrum was col- lected every 2 min to show the changes in the PCr and Pi content of the arm skeletal muscle tissue. "0-P= N-H ring activity NH2 C=NH2 + ADP ATP + C=NH2 during CH3-N recovery CH3-N CH2 ÇH2 The synthesis of phosphocreatine is unfavorable. If dur- ing extended periods of rest, e.g., sleeping at night, what must be the ADP/ATP ratio if the resting level of PCr/Cr is 30/1? CO- čoo- Phosphocreatine Creatine
Transcribed Image Text:(a) the left shows a 31P NMR spectrum of the arm of a control female subject at rest, and the diagram on the right the changes measured in the creatine and phosphocreatine levels of the arm at rest and exercise. To illustrate how the ADP phosphorylative capacity was measured, the diagram below on PCr 10L Exer -cise Еxer Rest cise Rest PCr/Pi = 9 PCr CATP YATP ВАТР Pi SP of 20 25 10 15 20 15 5 10 15 ppm Time(min) 31P NMR spectrum of the arm of a control sub- ject at rest showing characteristic resonance features for the phosphate residues of ATP, phosphocreatine (PCr), and Pi. At rest the PCr/Pi ratio is ordinarily - 8-9. Isokinetic ergometer exercise of the control female subject showing intervals of rest and exercise. To obtain this graph, a 3'P NMR spectrum was col- lected every 2 min to show the changes in the PCr and Pi content of the arm skeletal muscle tissue. "0-P= N-H ring activity NH2 C=NH2 + ADP ATP + C=NH2 during CH3-N recovery CH3-N CH2 ÇH2 The synthesis of phosphocreatine is unfavorable. If dur- ing extended periods of rest, e.g., sleeping at night, what must be the ADP/ATP ratio if the resting level of PCr/Cr is 30/1? CO- čoo- Phosphocreatine Creatine
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