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The structures of the amino acids leucine and isoleucine are shown: H N-C-C CH₂ CH HỌC CH, Leucine H OH H H H ₂0 OH CH H₂C CH₂ CH₂ Isoleucine a. Explain how the structure of amino acids determine the function. b. A mutation occurred in DNA of a globular enzyme. If the leucine amino acids were found within the active site of the enzyme, describe the effect this change is likely to have on enzymatic function. c. If a mutation in the DNA of a globular enzyme changed all of the leucine amino acids to isoleucine, predict how the relative position of the amino acid in the tertiary structure of the protein would be affected when the protein is placed in an aqueous solution. d. Justify your prediction by providing evidence that supports your claim.

The structures of the amino acids leucine and isoleucine are shown: H N-C-C CH₂ CH HỌC CH, Leucine H OH H H H ₂0 OH CH H₂C CH₂ CH₂ Isoleucine a. Explain how the structure of amino acids determine the function. b. A mutation occurred in DNA of a globular enzyme. If the leucine amino acids were found within the active site of the enzyme, describe the effect this change is likely to have on enzymatic function. c. If a mutation in the DNA of a globular enzyme changed all of the leucine amino acids to isoleucine, predict how the relative position of the amino acid in the tertiary structure of the protein would be affected when the protein is placed in an aqueous solution. d. Justify your prediction by providing evidence that supports your claim.

Biochemistry
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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The structures of the amino acids leucine and isoleucine are shown: H 0 OH H CH, CH H₂C CH₂ Leucine CH H₂C OH CH₂ CH₂ Isoleucine a. Explain how the structure of amino acids determine the function. b. A mutation occurred in DNA of a globular enzyme. If the leucine amino acids were found within the active site of the enzyme, describe the effect this change is likely to have on enzymatic function. c. If a mutation in the DNA of a globular enzyme changed all of the leucine amino acids to isoleucine, predict how the relative position of the amino acid in the tertiary structure of the protein would be affected when the protein is placed in an aqueous solution. d. Justify your prediction by providing evidence that supports your claim.
Transcribed Image Text:The structures of the amino acids leucine and isoleucine are shown: H 0 OH H CH, CH H₂C CH₂ Leucine CH H₂C OH CH₂ CH₂ Isoleucine a. Explain how the structure of amino acids determine the function. b. A mutation occurred in DNA of a globular enzyme. If the leucine amino acids were found within the active site of the enzyme, describe the effect this change is likely to have on enzymatic function. c. If a mutation in the DNA of a globular enzyme changed all of the leucine amino acids to isoleucine, predict how the relative position of the amino acid in the tertiary structure of the protein would be affected when the protein is placed in an aqueous solution. d. Justify your prediction by providing evidence that supports your claim.
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