The results of a multicenter clinical trial to determine the safety and efficacy of the pancreatic lipase inhibitor, Xenical, was reported (Ingersoll, 1997). Xenical is used to block the absorption of dietary fat. The article reported that more than 4000 patients in the U.S. and Europe were randomized to receive Xenical or a placebo in a parallel groups study. After one year, 57% of those receiving Xenical had lost at least 5% of their body weight, as opposed to 31% of those receiving a placebo. Assume that exactly 4000 patients were in the study, and that 2000 were randomized to receive a placebo and 2000 received Xenical. Please Compute a 95% confidence interval for the “relative risk” of losing at least 5% of body weight for those receiving Xenical relative to those receiving placebo
The results of a multicenter clinical trial to determine the safety and efficacy of the pancreatic lipase inhibitor, Xenical, was reported (Ingersoll, 1997). Xenical is used to block the absorption of dietary fat. The article reported that more than 4000 patients in the U.S. and Europe were randomized to receive Xenical or a placebo in a parallel groups study. After one year, 57% of those receiving Xenical had lost at least 5% of their body weight, as opposed to 31% of those receiving a placebo. Assume that exactly 4000 patients were in the study, and that 2000 were randomized to receive a placebo and 2000 received Xenical. Please Compute a 95% confidence interval for the “relative risk” of losing at least 5% of body weight for those receiving Xenical relative to those receiving placebo. Can the drug be considered effective?
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