The possible role of glutamatergic pathways in the pathophysiology of schizophrenia has been highlighted in recent years. Specifically, there has been talk of possible glutamatergic hyperfunction. How would this hyperfunction affect the dopaminergic pathways?

Biochemistry
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ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
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The possible role of glutamatergic pathways in the pathophysiology of schizophrenia has been highlighted in recent years. Specifically, there has been talk of possible glutamatergic hyperfunction. How would this hyperfunction affect the dopaminergic pathways?

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In schizophrenia dopamine release is impaired. It means in schizophrenic patients the level of dopamine is increased abruptly in the cortex region of the brain. Higher dopamine levels in the brain cause delusions, hallucinations and disorganized thinking. High levels of dopamine is schizophrenic patients is from so many decades, But glutamatergic receptor involvement in the schizophrenic patients is discovered recently. 

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