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That pathological finding in Alzheimer's due to tau protein alterations are called: O Amyloid plaques O Vascular dementia lesions O Neurofibrilary tangles O Infarctions

That pathological finding in Alzheimer's due to tau protein alterations are called: O Amyloid plaques O Vascular dementia lesions O Neurofibrilary tangles O Infarctions

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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### Pathological Findings in Alzheimer's Disease In Alzheimer's disease, specific pathological findings are associated with alterations in tau protein. These pathological manifestations are crucial for understanding the progression and impact of the disease on the brain. One of the key pathological features due to tau protein alterations in Alzheimer’s is: **Question:** What pathological finding in Alzheimer’s due to tau protein alterations are called: - ( ) Amyloid plaques - ( ) Vascular dementia lesions - (X) Neurofibrillary tangles - ( ) Infarctions **Explanation:** Neurofibrillary tangles are composed of hyperphosphorylated tau protein, which forms inside neurons. These tangles disrupt the normal function of the cells, leading to their death. This is a hallmark characteristic observed in Alzheimer's disease pathology. ### Understanding Other Terms: - **Amyloid Plaques:** These are abnormal clusters of protein fragments, composed mainly of beta-amyloid, that build up between neurons. - **Vascular Dementia Lesions:** These are associated with a decline in thinking skills caused by conditions that block or reduce blood flow to various regions of the brain, limiting the delivery of oxygen and essential nutrients. - **Infarctions:** These refer to areas of dead tissue due to the loss of blood supply, often related to strokes. By understanding these pathological elements, researchers and clinicians can better diagnose and develop treatments for Alzheimer's disease.
Transcribed Image Text:### Pathological Findings in Alzheimer's Disease In Alzheimer's disease, specific pathological findings are associated with alterations in tau protein. These pathological manifestations are crucial for understanding the progression and impact of the disease on the brain. One of the key pathological features due to tau protein alterations in Alzheimer’s is: **Question:** What pathological finding in Alzheimer’s due to tau protein alterations are called: - ( ) Amyloid plaques - ( ) Vascular dementia lesions - (X) Neurofibrillary tangles - ( ) Infarctions **Explanation:** Neurofibrillary tangles are composed of hyperphosphorylated tau protein, which forms inside neurons. These tangles disrupt the normal function of the cells, leading to their death. This is a hallmark characteristic observed in Alzheimer's disease pathology. ### Understanding Other Terms: - **Amyloid Plaques:** These are abnormal clusters of protein fragments, composed mainly of beta-amyloid, that build up between neurons. - **Vascular Dementia Lesions:** These are associated with a decline in thinking skills caused by conditions that block or reduce blood flow to various regions of the brain, limiting the delivery of oxygen and essential nutrients. - **Infarctions:** These refer to areas of dead tissue due to the loss of blood supply, often related to strokes. By understanding these pathological elements, researchers and clinicians can better diagnose and develop treatments for Alzheimer's disease.
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