The pathway below shows the synthesis of serotonin (an important neurotransmitter). What I want you to NOT focus on is the REACTION taking place but focus on the INTERACTION that the enzyme, the substrate and the product have. What I mean by that is HOW will each of the molecules fit or not fit with each other and WHY? You don't need to look this up, just use your knowledge about chemical and physical properties of molecules in general. Is the affinity of Tryptophan higher or lower than the affinity of 5-hydoxytryptophan for the а. enzyme tryptophan hydroxylase? WHY? b. Is the affinity of Serotonin higher or lower than the affinity of 5-hydroxytrptophan for the enzyme 5-HTP decarboxylase? OH Tryptophan NH2 HN- O2 Tetrahydrobiopterine Tryptophan hydroxylase Tryptophan-5-monooxygenase Hydroxytetra- hydrobiopterine HQ 5-hydroxytryptophan (5-HTP) HO, HN- NH2 Pyridoxalphospate| 5-HTP decarboxylase Aromatic amino acid decarboxylase но Serotonin 5-hydroxytryptamine (5-НТ) HN NH2

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