The Na"/glucose symport transports glucose from the lumen of the small in-testine into cells lining the lumen. Transport of 1 glucose molecule is directlycoupled to the transport of 1 Na* ion into the cell.1 Na"out + 1 glucose,ut→1 Na¨m+1 glucose.Assume the following conditions at 37 °C: [Na"Jm = 12 mM, [Na"Jout =145mM, [glucose]out =28 µM, and A =-72 mV (inside negative).(a) What is AG for transport of Na* from outside to inside under theseconditions?(b) What is the upper limit for [glucose], under these conditions?(c) Which of the two hypothetical symports shown below (A or B) wouldachieve the highest concentration of [glucose]n under the conditionsdescribed above? Briefly explain your choice.A: 1 Na"out +2 glucoseut + 1 Na" in +2 glucosenB: 2 Na1+1 glucoseut → 2 Na in +1 glucosenout

Given, Temperature =37° C[Na+]in =12 mM[Na+]out = 145 mM[glucose]out =28 μM∆ψ=-72 mV

Answered: The Na"/glucose symport transports…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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estion 5 of 15 > Intestinal epithelial cells pump glucose into the cell against its concentration gradient using the Nat-glucose symporter. Recall that the Na+ concentration is significantly higher outside the cell than inside the cell. The symporter couples the "downhill" transport of two Na+ ions into the cell to the "uphill" transport of glucose into the cell. AGgluc If the Na+ concentration outside the cell ([Na+]out) is 143 mM and that inside the cell ([Na+]in) is 19.0 mM, and the cell potential is -53.0 mV (inside negative), calculate the maximum energy available for pumping a mole of glucose into the cell. Assume the temperature is 37 °C. = kJ mol Attempt 14 What is the maximum ratio of [glucose] in to [glucose lout that could theoretically be produced if the energy coupling were 100% efficient? 3.3 x 10-4 O 1.13 3.0 × 10³ 8.01
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