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The Na+/glucose Cotransporter The active transport of glucose is mediated by the Na+/glucose cotransporter. This is a symporter; that is, both the sodium ion and the glucose molecule are passing through the membrane in the same direction:  sodium DOWN its gradient of about 140 mM outside to 10 mM inside while glucose is going UP its gradient (0.005 mM -> 5 mM) T=37oC and Vm = -70 mV CALCULATE THE ΔGin for Na+ (show work)  – and is this enough energy to move glucose in?  Or do you need to move 2 Na+ in for each glucose co-transported in?  Explain

The Na+/glucose Cotransporter The active transport of glucose is mediated by the Na+/glucose cotransporter. This is a symporter; that is, both the sodium ion and the glucose molecule are passing through the membrane in the same direction:  sodium DOWN its gradient of about 140 mM outside to 10 mM inside while glucose is going UP its gradient (0.005 mM -> 5 mM) T=37oC and Vm = -70 mV CALCULATE THE ΔGin for Na+ (show work)  – and is this enough energy to move glucose in?  Or do you need to move 2 Na+ in for each glucose co-transported in?  Explain

Biochemistry
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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  1. The Na+/glucose Cotransporter

The active transport of glucose is mediated by the Na+/glucose cotransporter.

This is a symporter; that is, both the sodium ion and the glucose molecule are passing through the membrane in the same direction:

 sodium DOWN its gradient of about

  • 140 mM outside to
  • 10 mM inside

while glucose is going UP its gradient (0.005 mM -> 5 mM)

T=37oC and Vm = -70 mV

CALCULATE THE ΔGin for Na+ (show work)  – and is this enough energy to move glucose in?  Or do you need to move 2 Na+ in for each glucose co-transported in?  Explain

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