The most common form of colorblindness is a recessive, sex-linked hereditary con dition caused by a defect on the X chromosome. Females are XX, while males are XY. Individuals inherit one chromosome from each parent, with equal probability; for example, an individual has a 50% chance of inheriting their father's X chromosome, and a 50% chance of inheriting their father's Y chromosome. If a male has an X chromosome with the defect, he is colorblind. However, a female with only one defective X chromo some will not be colorblind. Thus, colorblindness is more common in males than females; 7% of males are colorblind but only 0.5% of females are colorblind. (a) Assume that the X chromosome with the wild-type allele is X+ and the one with the disease allele is X. What is the expected frequency of each possible female genotype: X+X+, X+X¯, and X-X-? What is the expected frequency of each possible male genotype: X+ Y and X-Y? (b) Suppose that two parents are not colorblind. What is the probability that they have a colorblind child?

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
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Chapter1: The Human Body: An Orientation
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The most common form of colorblindness is a recessive, sex-linked hereditary con dition caused by a defect on the X chromosome. Females are XX, while males are XY. Individuals inherit one chromosome from each parent, with equal probability; for example, an individual has a 50% chance of inheriting their father's X chromosome, and a 50% chance of inheriting their father's Y chromosome. If a male has an X chromosome with the defect, he is colorblind. However, a female with only one defective X chromo some will not be colorblind. Thus, colorblindness is more common in males than females; 7% of males are colorblind but only 0.5% of females are colorblind. (a) Assume that the X chromosome with the wild-type allele is X+ and the one with the disease allele is X. What is the expected frequency of each possible female genotype: X+X+, X+X¯, and X-X-? What is the expected frequency of each possible male genotype: X+ Y and X-Y? (b) Suppose that two parents are not colorblind. What is the probability that they have a colorblind child?
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