The hydrolysis of an amide often requires harsh conditions, high temperatures, or a special enzyme. Identify which of the following statements does NOT provide a reason for this lack of reactivity. A) The pka of NH* is ~10 and the pka of H₂O is -16. B) The nitrogen of the amide can donate electrons to make a resonance structure that stabilizes the partial positive charge on the carbon. C) -NH, is not as stable of a leaving group as - OH, since it is less electronegative. D) There is significant 'double-bond' character between the carbon and nitrogen in an amide.

The hydrolysis of an amide often requires harsh conditions, high temperatures, or a special enzyme. Identify which of the following statements does NOT provide a reason for this lack of reactivity. A) The pka of NH* is ~10 and the pka of H₂O is -16. B) The nitrogen of the amide can donate electrons to make a resonance structure that stabilizes the partial positive charge on the carbon. C) -NH, is not as stable of a leaving group as - OH, since it is less electronegative. D) There is significant 'double-bond' character between the carbon and nitrogen in an amide.

Chemistry

10th Edition

ISBN:9781305957404

Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Chapter1: Chemical Foundations

Section: Chapter Questions

Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...

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