The hydrolysis of an amide often requires harsh conditions, high temperatures, or a special enzyme. Identify which of the following statements does NOT provide a reason for this lack of reactivity. A) The pka of NH* is ~10 and the pka of H₂O is -16. B) The nitrogen of the amide can donate electrons to make a resonance structure that stabilizes the partial positive charge on the carbon. C) -NH, is not as stable of a leaving group as - OH, since it is less electronegative. D) There is significant 'double-bond' character between the carbon and nitrogen in an amide.
The hydrolysis of an amide often requires harsh conditions, high temperatures, or a special enzyme. Identify which of the following statements does NOT provide a reason for this lack of reactivity. A) The pka of NH* is ~10 and the pka of H₂O is -16. B) The nitrogen of the amide can donate electrons to make a resonance structure that stabilizes the partial positive charge on the carbon. C) -NH, is not as stable of a leaving group as - OH, since it is less electronegative. D) There is significant 'double-bond' character between the carbon and nitrogen in an amide.
Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
Section: Chapter Questions
Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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Catalysis and Enzymatic Reactions
Catalysis is the kind of chemical reaction in which the rate (speed) of a reaction is enhanced by the catalyst which is not consumed during the process of reaction and afterward it is removed when the catalyst is not used to make up the impurity in the product. The enzymatic reaction is the reaction that is catalyzed via enzymes.
Lock And Key Model
The lock-and-key model is used to describe the catalytic enzyme activity, based on the interaction between enzyme and substrate. This model considers the lock as an enzyme and the key as a substrate to explain this model. The concept of how a unique distinct key only can have the access to open a particular lock resembles how the specific substrate can only fit into the particular active site of the enzyme. This is significant in understanding the intermolecular interaction between proteins and plays a vital role in drug interaction.
Question
Transcribed Image Text:The hydrolysis of an amide often requires harsh conditions, high temperatures, or
a special enzyme. Identify which of the following statements does NOT provide a
reason for this lack of reactivity.
A) The pka of NH * is ~10 and the pka of H₂O is
-16.
4
B) The nitrogen of the amide can donate
electrons to make a resonance structure that
stabilizes the partial positive charge on the
carbon.
C) -NH, is not as stable of a leaving group as -
OH, since it is less electronegative.
D) There is significant 'double-bond' character
between the carbon and nitrogen in an amide.
+
Transcribed Image Text:Proteins are long chains of repeating amino acids connected by peptide bonds.
The reverse reaction of peptide bond formation is the hydrolysis of an amide.
Peptide bonds are
A) very reactive with water
B) unreactive with water but easily hydrolyzed
under acidic conditions
C) unreactive with water but easily hydrolyzed
under basic conditions
D) unreactive with water and only slightly
reactive to hydrolysis under acidic conditions
+
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