Which of the following reducing agents is used in a reductive amination? You may choose more than one answer. H2, Pd/C NABH4

Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
Section: Chapter Questions
Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
icon
Related questions
icon
Concept explainers
Question

Please help me with both of these, I am very confused and would like to study

**Question:**

Which of the following reducing agents is used in a reductive amination? You may choose more than one answer.

**Options:**

- [ ] H2, Pd/C
- [ ] NaBH4
- [ ] NaBH3CN
- [ ] LiAlH4

**Explanation:**
Reductive amination is a process in organic chemistry where a carbonyl compound is converted into an amine through a reduction step. This process involves the formation of an imine or iminium ion intermediate, which is subsequently reduced to form the corresponding amine. Suitable reducing agents are crucial for the efficiency and success of the reaction. Common reducing agents for reductive amination include:

1. **Sodium Cyanoborohydride (NaBH3CN):**
   - Preferred due to its mild reducing properties which specifically reduce imines and iminium ions without affecting other functional groups.

2. **Hydrogen (H2) with Palladium on Carbon (Pd/C):**
   - Effective for the catalytic hydrogenation of imines; however, it is not as commonly used as NaBH3CN due to potential over-reduction or need for harsher conditions.

When preparing for this topic, it is essential to understand the role of each reducing agent and their applicability depending on the substrate and desired product.
Transcribed Image Text:**Question:** Which of the following reducing agents is used in a reductive amination? You may choose more than one answer. **Options:** - [ ] H2, Pd/C - [ ] NaBH4 - [ ] NaBH3CN - [ ] LiAlH4 **Explanation:** Reductive amination is a process in organic chemistry where a carbonyl compound is converted into an amine through a reduction step. This process involves the formation of an imine or iminium ion intermediate, which is subsequently reduced to form the corresponding amine. Suitable reducing agents are crucial for the efficiency and success of the reaction. Common reducing agents for reductive amination include: 1. **Sodium Cyanoborohydride (NaBH3CN):** - Preferred due to its mild reducing properties which specifically reduce imines and iminium ions without affecting other functional groups. 2. **Hydrogen (H2) with Palladium on Carbon (Pd/C):** - Effective for the catalytic hydrogenation of imines; however, it is not as commonly used as NaBH3CN due to potential over-reduction or need for harsher conditions. When preparing for this topic, it is essential to understand the role of each reducing agent and their applicability depending on the substrate and desired product.
**Question:**
Reductive amination is the process whereby which of the following is reduced to an amine?

**Options:**
- Nitrile
- Amide
- Imine
- Azide

Please select one of the above options.

**Explanation:**
Reductive amination is a chemical process in which an imine is reduced to form an amine. This reaction is commonly used in the synthesis of primary, secondary, and tertiary amines and involves the conversion of a carbonyl compound (such as an aldehyde or ketone) and ammonia or an amine, forming an imine intermediate which is then reduced to an amine.
Transcribed Image Text:**Question:** Reductive amination is the process whereby which of the following is reduced to an amine? **Options:** - Nitrile - Amide - Imine - Azide Please select one of the above options. **Explanation:** Reductive amination is a chemical process in which an imine is reduced to form an amine. This reaction is commonly used in the synthesis of primary, secondary, and tertiary amines and involves the conversion of a carbonyl compound (such as an aldehyde or ketone) and ammonia or an amine, forming an imine intermediate which is then reduced to an amine.
Expert Solution
trending now

Trending now

This is a popular solution!

steps

Step by step

Solved in 4 steps

Blurred answer
Knowledge Booster
Basics in Organic Reaction Mechanisms
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, chemistry and related others by exploring similar questions and additional content below.
Recommended textbooks for you
Chemistry
Chemistry
Chemistry
ISBN:
9781305957404
Author:
Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:
Cengage Learning
Chemistry
Chemistry
Chemistry
ISBN:
9781259911156
Author:
Raymond Chang Dr., Jason Overby Professor
Publisher:
McGraw-Hill Education
Principles of Instrumental Analysis
Principles of Instrumental Analysis
Chemistry
ISBN:
9781305577213
Author:
Douglas A. Skoog, F. James Holler, Stanley R. Crouch
Publisher:
Cengage Learning
Organic Chemistry
Organic Chemistry
Chemistry
ISBN:
9780078021558
Author:
Janice Gorzynski Smith Dr.
Publisher:
McGraw-Hill Education
Chemistry: Principles and Reactions
Chemistry: Principles and Reactions
Chemistry
ISBN:
9781305079373
Author:
William L. Masterton, Cecile N. Hurley
Publisher:
Cengage Learning
Elementary Principles of Chemical Processes, Bind…
Elementary Principles of Chemical Processes, Bind…
Chemistry
ISBN:
9781118431221
Author:
Richard M. Felder, Ronald W. Rousseau, Lisa G. Bullard
Publisher:
WILEY