Does the drug have an amine here? I am confused. Can none of the nitrogrens become ionized? AzaareneNNCarbonylCH3MethylAmineNBenzene RingN-OF)Aryl FluorideRisperidone(Final Product)

This is Risperidone drug and it carry so many numbers of functional group. Functional groups are…

Answered: Does the drug have an amine here? I am…

Organic Chemistry: A Guided Inquiry

2nd Edition

ISBN:9780618974122

Author:Andrei Straumanis

Publisher:Andrei Straumanis

Chapter27: Amines

Section: Chapter Questions

Problem 2E

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Does the drug have an amine here? I am confused. Can none of the nitrogrens become ionized?

Azaarene
N
N
Carbonyl
CH3
Methyl
Amine
N
Benzene Ring
N-O
F)
Aryl Fluoride
Risperidone
(Final Product)

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Oh okay. So that amine can be ionized. Under what conditions? Typically, at physiological pH, that amine would not be ionized. So when would it be ionized and where in the body does that happen? Can you give specific pKa values?

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