the hormone estradiolhas a partition coefficient of 3.2 between 1-octanol and water. How many extractions would need to be completed to recover > 99% from 250 mL of saturated solution using 100 mL of 1-octanol per extraction? The variables given are listed below along with the solution. In this scenario, it would require 5 extractions to recover > 99% of estradiol! Typically extractions are carried out only 2 or 3 times because the partition coefficient is usually larger than 3.2 and there are equal amounts of organic solvent and the aqueous layer.
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For example, the hormone estradiolhas a partition coefficient of 3.2 between 1-octanol and water. How many extractions would need to be completed to recover > 99% from 250 mL of saturated solution using 100 mL of 1-octanol per extraction? The variables given are listed below along with the solution. In this scenario, it would require 5 extractions to recover > 99% of estradiol! Typically extractions are carried out only 2 or 3 times because the partition coefficient is usually larger than 3.2 and there are equal amounts of organic solvent and the aqueous layer.
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