The genetic disorder sickle-cell anemia occurs when the amino acid valine takes the place of glutamate during translation of a hemoglobin chain. Using the table of codons below, determine the mutation in DNA that produces this disorder. 1st position ↓ U C A G Select one: U serine phenylalanine phenylalanine serine leucine leucine serine serine leucine leucine leucine leucine isoleucine isoleucine isoleucine methionine Table of mRNA Codons 2nd position valine valine valine valine C proline proline proline proline alanine alaninc alanine alanine a. CUC changes to CAG b. GA A changes to GUU A tyrosine tyrosine c. CTT changes to CAT d. C A G changes to CTC stop stop threonine asparagine threonine asparagine threonine threonine histidine histidine glutamine glutamine lysine lysine aspartate aspartate glutamate glutamate G cysteine cysteine stop tryptophan arginine arginine arginine arginine serine serine arginine arginine glycine glycine glycine glycine 3rd position DUMO C G DUMO A G DUMO с A G U C A G

Human Anatomy & Physiology (11th Edition)
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Chapter1: The Human Body: An Orientation
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The genetic disorder sickle-cell anemia occurs when the amino acid valine takes the place of glutamate
during translation of a hemoglobin chain. Using the table of codons below, determine the mutation in
DNA that produces this disorder.
1st position
✓
U
C
A
G
Select one:
U
C
serine
phenylalanine
phenylalanine serine
leucine
serine
leucine
serine
leucine
leucine
leucine
leucine
isoleucine
isoleucine
isoleucine
methionine
Table of mRNA Codons
2nd position
valine
valine
valine
valine
proline
proline
proline
proline
alanine
alaninc
alanine
alanine
A
tyrosine
tyrosine
a. CUC changes to C AG
b.
GAA changes to GUU
c. CTT changes to CAT
d. C A G changes to CTC
stop
stop
threonine asparagine
threonine asparagine
threonine
threonine
histidine
histidine
arginine
arginine
glutamine
arginine
glutamine arginine
lysine
lysine
G
cysteine
cysteine
stop
tryptophan
aspartate
aspartate
glutamate
glutamate
serine
serine
arginine
arginine
glycine
glycine
glycine
glycine
3rd position
DCMO
U
С
A
G
U
C
A
G
DUMO
с
A
G
DUMO
C
A
G
Transcribed Image Text:The genetic disorder sickle-cell anemia occurs when the amino acid valine takes the place of glutamate during translation of a hemoglobin chain. Using the table of codons below, determine the mutation in DNA that produces this disorder. 1st position ✓ U C A G Select one: U C serine phenylalanine phenylalanine serine leucine serine leucine serine leucine leucine leucine leucine isoleucine isoleucine isoleucine methionine Table of mRNA Codons 2nd position valine valine valine valine proline proline proline proline alanine alaninc alanine alanine A tyrosine tyrosine a. CUC changes to C AG b. GAA changes to GUU c. CTT changes to CAT d. C A G changes to CTC stop stop threonine asparagine threonine asparagine threonine threonine histidine histidine arginine arginine glutamine arginine glutamine arginine lysine lysine G cysteine cysteine stop tryptophan aspartate aspartate glutamate glutamate serine serine arginine arginine glycine glycine glycine glycine 3rd position DCMO U С A G U C A G DUMO с A G DUMO C A G
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