The figure above depicts the biochemical pathway involving synthesis of cholesterol. Excess precursors, like acetyl CoA, could lead to overproduction of cholesterol. Once there is an excessive production of cholesterol, certain cardiovascular risks could amplify. In the management of excess cholesterol production, do you think that targeting this pathway would provide a clinical value? Why, or why not?

Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
icon
Related questions
Question
The figure above depicts the biochemical pathway involving synthesis of cholesterol. Excess precursors, like acetyl CoA, could lead to overproduction of cholesterol. Once there is an excessive production of cholesterol, certain cardiovascular risks could amplify. In the management of excess cholesterol production, do you think that targeting this pathway would provide a clinical value? Why, or why not?
Glucose
Fatty acids
Acetyl-CoA
Leucine
HMG-COA
HMG-CoA reductase
Mevalonic acid
Mevalonate kinase
Isopentenyl-
pyrophosphate
Isopentenyl-
TRNA's
Farnesylpyrophosphate
Dolichol
Squalene
Haem A
Lanosterol
Ubiquinone
7-Dehydro-
cholesterol
Desmosterol
Steroid hormones
Cholesterol
- - --
Bile acids
Transcribed Image Text:Glucose Fatty acids Acetyl-CoA Leucine HMG-COA HMG-CoA reductase Mevalonic acid Mevalonate kinase Isopentenyl- pyrophosphate Isopentenyl- TRNA's Farnesylpyrophosphate Dolichol Squalene Haem A Lanosterol Ubiquinone 7-Dehydro- cholesterol Desmosterol Steroid hormones Cholesterol - - -- Bile acids
Expert Solution
steps

Step by step

Solved in 2 steps

Blurred answer
Similar questions
Recommended textbooks for you
Biochemistry
Biochemistry
Biochemistry
ISBN:
9781319114671
Author:
Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:
W. H. Freeman
Lehninger Principles of Biochemistry
Lehninger Principles of Biochemistry
Biochemistry
ISBN:
9781464126116
Author:
David L. Nelson, Michael M. Cox
Publisher:
W. H. Freeman
Fundamentals of Biochemistry: Life at the Molecul…
Fundamentals of Biochemistry: Life at the Molecul…
Biochemistry
ISBN:
9781118918401
Author:
Donald Voet, Judith G. Voet, Charlotte W. Pratt
Publisher:
WILEY
Biochemistry
Biochemistry
Biochemistry
ISBN:
9781305961135
Author:
Mary K. Campbell, Shawn O. Farrell, Owen M. McDougal
Publisher:
Cengage Learning
Biochemistry
Biochemistry
Biochemistry
ISBN:
9781305577206
Author:
Reginald H. Garrett, Charles M. Grisham
Publisher:
Cengage Learning
Fundamentals of General, Organic, and Biological …
Fundamentals of General, Organic, and Biological …
Biochemistry
ISBN:
9780134015187
Author:
John E. McMurry, David S. Ballantine, Carl A. Hoeger, Virginia E. Peterson
Publisher:
PEARSON