The citric acid cycle is shown. The methyl carbon in acetyl CoA is labeled with C14C14 (shown in red). Identify which of the carbons in each intermediate will be labeled in the first round of the cycle by selecting the indicated carbon(s). Each question has multiple options except citrate.  Which carbon in citrate will contain C14? 4 1 3 2 Which carbon(s) in isocitrate will contain C14?

Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
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The citric acid cycle is shown. The methyl carbon in acetyl CoA is labeled with C14C14 (shown in red). Identify which of the carbons in each intermediate will be labeled in the first round of the cycle by selecting the indicated carbon(s). Each question has multiple options except citrate. 

Which carbon in citrate will contain C14?
4
1
3
2
Which carbon(s) in isocitrate will contain C14?
1
2
3
4
5
6
Which carbon(s) in α‑ketoglutarate will contain C14?
1
2
3
4
5
Which carbon(s) in succinyl‑CoA will contain C14?
1
2
3
4
Which carbon(s) in succinate will contain C14?
1
2
3
4
Which carbon(s) in fumarate will contain C14?
1
2
3
4
Which carbon(s) in malate will contain C14?
1
2
3
4
Which carbon(s) in oxaloacetate will contain C14?
1
2
3
4
NADH
+H*
NAD
Fumarate
OH
Malate
H₂O
FADH₂
FAD
Acetyl-CoA
3
H₂C
Succinate
CO₂
Oxaloacetate
SCOA COASH
H₂O
COA
GTP
O₂C.
COAS
GDP + Pi
HO
I
Citrate
NAD+
NADH+HK
CO₂
CO₂
Succinyl-CoA
2
OH
CO₂
Isocitrate
NAD+
COASH
NADH+H*
O -ketoglutarate
Transcribed Image Text:NADH +H* NAD Fumarate OH Malate H₂O FADH₂ FAD Acetyl-CoA 3 H₂C Succinate CO₂ Oxaloacetate SCOA COASH H₂O COA GTP O₂C. COAS GDP + Pi HO I Citrate NAD+ NADH+HK CO₂ CO₂ Succinyl-CoA 2 OH CO₂ Isocitrate NAD+ COASH NADH+H* O -ketoglutarate
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