The birth of this child prompted the Dentons' physician to order a chromosome study of parents and child. The results of the study are shown in the accompanying fig ure. Chromosome banding was done, and all chromo somes were normal in these individuals, except some copies of number 6 and number 12. The number-6 and number-12 chromosomes of mother, father, and child are shown in the figure (the number 6 chromosomes are the larger pair) III D IDO

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8.18 Irradiatioh of Drosophila sperm produces transloca-
tions between the X chromosome and autosomes,
between the Y chromosome and autosomes, and between
different autosomes. Translotations between the X and Y
chromosomes are not produced. Explain the absence of
X-Y translocations.
The birth of this child prompted the Dentons' physician
to order a chromosome study of parents and child. The
results of the study are shown in the accompanying fig-
ure. Chromosome banding was done, and all chromo-
somes were normal in these individuals, except some
copies of number 6 and number 12. The number-6 and
number-12 chromosomes of mother, father, and child are
shown in the figure (the number 6 chromosomes are the
larger pair):
Child
Mrs. Denton
Mr. Denton
a. Does either parent have an abnormal karyotype? If
so, which parent has it, and what is the nature of the
abnormality?
b. How did the child's karyotype arise? (What pairing
and segregation events took place in the parents?)
e. Why is the child phenotypically defective?
d. What can this couple expect to happen in subse-
quent concéptions?
What medical help, if any, can be offered to the couple?
6.
IDO IOI
IDO ID
IO IIXII IO O ID
IDO I-OID
IDO IO ID
OID III D
Transcribed Image Text:8.18 Irradiatioh of Drosophila sperm produces transloca- tions between the X chromosome and autosomes, between the Y chromosome and autosomes, and between different autosomes. Translotations between the X and Y chromosomes are not produced. Explain the absence of X-Y translocations. The birth of this child prompted the Dentons' physician to order a chromosome study of parents and child. The results of the study are shown in the accompanying fig- ure. Chromosome banding was done, and all chromo- somes were normal in these individuals, except some copies of number 6 and number 12. The number-6 and number-12 chromosomes of mother, father, and child are shown in the figure (the number 6 chromosomes are the larger pair): Child Mrs. Denton Mr. Denton a. Does either parent have an abnormal karyotype? If so, which parent has it, and what is the nature of the abnormality? b. How did the child's karyotype arise? (What pairing and segregation events took place in the parents?) e. Why is the child phenotypically defective? d. What can this couple expect to happen in subse- quent concéptions? What medical help, if any, can be offered to the couple? 6. IDO IOI IDO ID IO IIXII IO O ID IDO I-OID IDO IO ID OID III D
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(1) The different forms of chromosomal mutations (translocations, deletions, duplications, and inversions.

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