The allele of the gene responsible for the lung disorder, cystic fibrosis rose to prominence in Europe in the 1800s. Cystic fibrosis disease results from thick mucus accumulating in the lungs, which occurs in individuals who are homozygous for the CF allele. A pleiotropic effect is that heterozygous individuals are less likely to suffer from diarrhea. During the European cholera epidemics of the 1800s, resistance against diarrhea conferred a survival advantage such that approximately one in every 400 people in some European populations have cystic fibrosis. Fill in the table below with the genotype and allele frequencies for this 1 in 400 occurrence and provide the Hardy-Weinberg principle model you will be using. (Assume that individuals with the cystic fibrosis trait (CF) reproduce normally and that good sanitation means that there is currently no fitness advantage to diarrhea resistance.) phenotype CF DR normal (totals) Genotype cc Cc CC Number of Individuals 1 ______ ______ (400) Genotype frequencies _____ .095 ______ (1.0) Allele c C Allele frequency ______ ______ (1.0
The allele of the gene responsible for the lung disorder, cystic fibrosis rose to prominence in Europe in the 1800s. Cystic fibrosis disease results from thick mucus accumulating in the lungs, which occurs in individuals who are homozygous for the CF allele. A pleiotropic effect is that heterozygous individuals are less likely to suffer from diarrhea. During the European cholera epidemics of the 1800s, resistance against diarrhea conferred a survival advantage such that approximately one in every 400 people in some European populations have cystic fibrosis.
Fill in the table below with the genotype and allele frequencies for this 1 in 400 occurrence and provide the
| CF | DR | normal | (totals) | |
| Genotype | cc | Cc | CC | |
| Number of Individuals | 1 | ______ | ______ | (400) |
| Genotype frequencies | _____ | .095 | ______ | (1.0) |
| Allele | c | C | ||
| Allele frequency | ______ | ______ | (1.0) |
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