The adaptive immune system developed a strategy for monitoring the proteins synthesized in virtually any cell in the body, thereby preventing pathogens from ‘hiding out’ by adopting an intracellular lifestyle. To accomplish this, the immune system: Co-opted the ubiquitin-proteasome system used by cell for protein turnover Created a novel pathway using the immunoproteasome for generating peptides Created a novel pathway to express foreign proteins on the cell surface Took advantage of proteolytic enzymes present in endocytic vesicles

Human Heredity: Principles and Issues (MindTap Course List)
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Chapter17: Genes And The Immune System
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Problem 10QP: The Adaptive Immune Response Is a Specific Defense Against Infection Researchers have been having a...
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The adaptive immune system developed a strategy for monitoring the proteins synthesized in virtually any cell in the body, thereby preventing pathogens from ‘hiding out’ by adopting an intracellular lifestyle. To accomplish this, the immune system:

  1. Co-opted the ubiquitin-proteasome system used by cell for protein turnover
  2. Created a novel pathway using the immunoproteasome for generating peptides
  3. Created a novel pathway to express foreign proteins on the cell surface
  4. Took advantage of proteolytic enzymes present in endocytic vesicles
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