The activity of isocitrate dehydrogenase in E. coli is regulated by the covalent attachment of a phosphate group, which inactivates the enzyme. When acetate is the food source for a culture of E. coli, isocitrate dehydrogenase is phosphorylated. However, when glucose is added to the culture, the phosphate group is removed from isocitrate dehydrogenase. These observations indicate that acetate metabolism proceeds through the citric acid cycle *, while glucose metabolism proceeds through the gluconeogenesis pathway
The activity of isocitrate dehydrogenase in E. coli is regulated by the covalent attachment of a phosphate group, which inactivates the enzyme. When acetate is the food source for a culture of E. coli, isocitrate dehydrogenase is phosphorylated. However, when glucose is added to the culture, the phosphate group is removed from isocitrate dehydrogenase. These observations indicate that acetate metabolism proceeds through the citric acid cycle *, while glucose metabolism proceeds through the gluconeogenesis pathway
Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
Section: Chapter Questions
Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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Organic Chemistry of Metabolic Pathways
Metabolic pathways allude to the arrangement of chemical catalyzed reactions that lead to the transformation of a substance into the final product. Metabolic pathways incorporate a progression of reaction where the substrate is changed continuously and the transitional metabolites are persistently recovered.
Glucogenesis
Glucogenesis is a metabolic pathway in which glucose is produced from carbon substrates that are not carbohydrates. This process is observed in plants, animals, fungi, bacteria and other micro organisms. The general definition for glucogenesis or gluconeogenesis is as follows,
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The answer option for the drop down menu are citric acid cycle, gluconeogenesis pathway, and glyoxylate cycle.

Transcribed Image Text:The activity of isocitrate dehydrogenase in E. coli is regulated by the covalent attachment of a phosphate group, which inactivates the
enzyme. When acetate is the food source for a culture of E. coli, isocitrate dehydrogenase is phosphorylated. However, when glucose is
added to the culture, the phosphate group is removed from isocitrate dehydrogenase. These observations indicate that acetate
metabolism proceeds through the citric acid cycle
,while glucose metabolism proceeds through the
gluconeogenesis pathway
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