Test for differences (a) between ovalbumin-sensitized and nonser chree different exposures, and (c) interaction. Let a = .05 for alL

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Test for differences (a) between ovalbumin-sensitized and nonsensitized outcomes, (b) among the
three different exposures, and (c) interaction. Let a = .05 for all tests.
Transcribed Image Text:Test for differences (a) between ovalbumin-sensitized and nonsensitized outcomes, (b) among the three different exposures, and (c) interaction. Let a = .05 for all tests.
16. In a study of pulmonary effects on guinea pigs, Lacroix et al. (A-30) exposed 18 ovalbumin-
sensitized guinea pigs and 18 nonsensitized guinea pigs to regular air, benzaldehyde, and
acetaldehyde. At the end of exposure, the guinea pigs were anesthetized and allergic
responses were assessed in bronchoalveolar lavage (BAL). The following table shows the
alveolar cell count (x10°) by treatment group for the ovalbumin-sensitized and nonsensitized
guinea pigs.
Ovalbumin-Sensitized
Treatment
Alveolar Count ×106
no
acetaldehyde
acetaldehyde
acetaldehyde
acetaldehyde
acetaldehyde
acetaldehyde
air
air
49.90
50.60
50.35
no
no
no
44.10
36.30
no
no
39.15
no
24.15
24.60
22.55
no
no
air
no
air
25.10
22.65
26.85
31.10
no
air
no
air
benzaldehyde
benzaldehyde
benzaldehyde
benzaldehyde
benzaldehyde
benzaldehyde
acetaldehyde
acetaldehyde
acetaldehyde
acetaldehyde
acetaldehyde
acetaldehyde
no
no
18.30
19.35
no
no
15.40
27.10
no
21.90
90.30
72.95
138.60
no
yes
yes
yes
80.05
69.25
31.70
40.20
63.20
59.10
79.60
yes
yes
yes
air
yes
air
yes
уes
air
air
уes
air
102.45
64.60
22.15
22.75
22.15
yes
air
yes
yes
yes
yes
yes
benzaldehyde
benzaldehyde
benzaldehyde
benzaldehyde
benzaldehyde
benzaldehyde
37.85
19.35
yes
66.70
yes
Source: Data provided courtesy of G. Lacroix, Docteur en Toxicologie.
Transcribed Image Text:16. In a study of pulmonary effects on guinea pigs, Lacroix et al. (A-30) exposed 18 ovalbumin- sensitized guinea pigs and 18 nonsensitized guinea pigs to regular air, benzaldehyde, and acetaldehyde. At the end of exposure, the guinea pigs were anesthetized and allergic responses were assessed in bronchoalveolar lavage (BAL). The following table shows the alveolar cell count (x10°) by treatment group for the ovalbumin-sensitized and nonsensitized guinea pigs. Ovalbumin-Sensitized Treatment Alveolar Count ×106 no acetaldehyde acetaldehyde acetaldehyde acetaldehyde acetaldehyde acetaldehyde air air 49.90 50.60 50.35 no no no 44.10 36.30 no no 39.15 no 24.15 24.60 22.55 no no air no air 25.10 22.65 26.85 31.10 no air no air benzaldehyde benzaldehyde benzaldehyde benzaldehyde benzaldehyde benzaldehyde acetaldehyde acetaldehyde acetaldehyde acetaldehyde acetaldehyde acetaldehyde no no 18.30 19.35 no no 15.40 27.10 no 21.90 90.30 72.95 138.60 no yes yes yes 80.05 69.25 31.70 40.20 63.20 59.10 79.60 yes yes yes air yes air yes уes air air уes air 102.45 64.60 22.15 22.75 22.15 yes air yes yes yes yes yes benzaldehyde benzaldehyde benzaldehyde benzaldehyde benzaldehyde benzaldehyde 37.85 19.35 yes 66.70 yes Source: Data provided courtesy of G. Lacroix, Docteur en Toxicologie.
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