ter is attached to 1 aspartate ligand, 1 cysteine ligand, and 2 histidine ligands. The glutamate residue on the bottom is hydrogen bonded to the histidine side chain. The pKa of the water that is attached on top is 7. Part a) If the cysteine ligand was changed to a histidine ligand, how would the pka of the water change? Explain. Part b) If the glutamate residue was changed to leucin

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The manganese ion in the center is attached to 1 aspartate ligand, 1 cysteine ligand, and 2 histidine ligands. The glutamate residue on the bottom is hydrogen bonded to the histidine side chain. The pKa of the water that is attached on top is 7.

Part a) If the cysteine ligand was changed to a histidine ligand, how would the pka of the water change? Explain.

Part b) If the glutamate residue was changed to leucine, how would the pka of the water change? Explain.

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