Suzuki-Miyaura coupling is a reliable method to make biaryl compounds (Ar-Ar'). The reaction is tolerant of a wide range of functional groups. What are some transformations that can be done to the acetyl group (CH3C-0) after the following Suzuki coupling? For example, Grignard reactions, Wittig reactions, imine/enamine formation, aldol condensations, reduction..... The world is big; keep exploring. OH Br B Pd(PPh3)4 NaOAc THF-H₂O + HO CH3 CH3

Suzuki-Miyaura coupling is a reliable method to make biaryl compounds (Ar-Ar'). The reaction is tolerant of a wide range of functional groups. What are some transformations that can be done to the acetyl group (CH3C-0) after the following Suzuki coupling? For example, Grignard reactions, Wittig reactions, imine/enamine formation, aldol condensations, reduction..... The world is big; keep exploring. OH Br B Pd(PPh3)4 NaOAc THF-H₂O + HO CH3 CH3

Chemistry

10th Edition

ISBN:9781305957404

Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Chapter1: Chemical Foundations

Section: Chapter Questions

Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...

See similar textbooks

Similar questions

-a, B-unsaturated ketones, aldehydes react with nucleophiles 1,2-addition (direct addition): by R-MgX, LiAlH4 1.4-addition (conjugate addition): by R₂CuLi (Gilman reagent), and most other nucleophiles 1) (CH3)2CuLi 2) H* + 1) -MgBr 2)H₂O+
Researchers have been able to conduct sequential ring closing metathesis tollowed by a cross-metathesis reaction, in an effort to create rings and add carbons. However, cross-metathesis can be challenging when there are strained alkenes present, as shown in this example with a final product of 8%. Fill in the missing structures from each reaction. OBn OBn OBn Ru Ph C33H3605 A ACO Ru Ph ŌAC C39H4409 B
please help me - please
Write whether it will be E1, E2, SN1, and/or SN2 Show the mechanism(s) Write the MAJOR product(s) State the stereochemistry of the product(s), when applicable. PLEASE DO THEM IN THE STRUCTURAL FORM THEY ARE WRITTEN.
Need help!
During the workup portion of the reaction of alkenes with HBr as described in the experiment provided, a student transferred the reaction mixture to a separatory funnel, rinsed the reaction flask with diethyl ether, and added the ether rinses to the separatory funnel. The student then added sodium bicarbonate to the separatory funnel. Extremely vigorous bubbling occurred. What did the student do wrong? Can they still isolate the product? If so describe the next steps the student should take to isolate the product.
Please don't provide handwriting solution
Why in suzuki coupling reactions does 1-bromo-4 iododo benzene react with the iodine atom rather than bromine?
10) Dr. Rashmi uses a rather specific three-steps procedure (described below) to cook up a spicy sugar derivative. Why does she make use of such a protocol? Describe the purpose of each steps. 1) acetone, cat. H* 2) 2,5-dimethylbenzyl bromide, NaH 3) H30*, r.t. он NH2 "NH2 'Buo "Buo ´OBu O'Bu
CH3 H3C, CH3 с. ZH CH3 CH3 `CH3 `CH3 % Ortho 63 45 30 16 In Section 23.2, we learned that all alkyl groups are ortho/para directors. However, the relative amounts of ortho and para products depend on the specific identity of the alkyl group, as shown here for the nitration of various alkylbenzenes. What trend do you % Meta 3 8 11 % Para 34 49 62 73 observe? What factor accounts for that trend? fo
(a) In an acid-catalyzed hydration, one of the following 10 carbon alkynes is expected to produce a single hydration product? Select the correct alkyne and draw the structure of the hydration product that is formed from this alkyne. (I) 2-decyne; (II) 3-decyne; (III) 4-decyne; (IV) 5-decyne; (V) none of these will give a single hydration product. (b) The reaction shown below gives Compound X as the major product. The mass spectrum of X is shown. Br2, H20 Compound X 100 - MS-IW-5644 80 60 40 - 20 - 20 40 60 80 100 120 140 160 180 200 220 m/z Considering the reactions of alkynes and the MS data, de duce which of following structures corresponds to X: Br Br HO, IV V I II II Support your answer with a reaction mechanism for fomation of X and identification of relevant peaks in the mass spectrum. 12 Relative Intensity
Please help answer the attached question....thank you!