Suppose you have compounds A-D at your disposal. Using these compounds, devise two different ways to make E. Which one of these methods is preferred, and why? Be sure to answer all parts. ONa OCH3 CH3I NaOCH, A B C E Part 1 out of 2 Method [1]: B + (select) CH3OH Method [2]: D + (select) E THF Next nart
Reactions of Ethers
Ethers (R-O-R’) are compounds formed by replacing hydrogen atoms of an alcohol (R-OH compound) or a phenol (C6H5OH) by an aryl/ acyl group (functional group after removing single hydrogen from an aromatic ring). In this section, reaction, preparation and behavior of ethers are discussed in the context of organic chemistry.
Epoxides
Epoxides are a special class of cyclic ethers which are an important functional group in organic chemistry and generate reactive centers due to their unusual high reactivity. Due to their high reactivity, epoxides are considered to be toxic and mutagenic.
Williamson Ether Synthesis
An organic reaction in which an organohalide and a deprotonated alcohol forms ether is known as Williamson ether synthesis. Alexander Williamson developed the Williamson ether synthesis in 1850. The formation of ether in this synthesis is an SN2 reaction.
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Suppose you have compounds A-D at your disposal. Using these compounds, devise two different ways to
make E. Which one of these methods is preferred, and why? Be sure to answer all parts.
ONa
OCH3
CH,I
NaOCH3
Part 1 out of 2
Method [1]:
B + (select)
E
CH3OH
Method [2]:
D + (select) v
> E
Hint
THE
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