Step 3: the phosphorylation of fructose 6-phosphate, is the first committedstep of glycolysis. This step is catalyzed by phosphofructokinase, anenzyme that can be regulated allosterically by many molecules (two of whichare ADP and phosphoenolpyruvate). Why is this regulation important?

Glycolysis is a sequence of metabolic reactions that breaks down glucose, a six-carbon sugar, into…

Answered: Step 3: the phosphorylation of fructose…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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Regarding cellular metabolism, mark the true statements: (a). Electrons from the oxidation of glycolysis are transferred to O2 in the TCA cycle (b).Flow in the citric acid cycle increases when the intracellular ratio [NADH/NAD+] is high (c).In microbial cells, the glyoxylate pathway indirectly allows the conversion of fatty acids into glucose (d).Anaplerotic reactions are enzymatic reactions whose kinetics do not follow the Michaelis-Menten model. (e).Gluconeogenesis is the pathway of glucose production from different precursors, such as glycerol, some amino acids and lactate
In the regulation of glycogen phosphorylase, which of the following statements is true? The inactive T form becomes activated when it gets dephosphorylated. The active R form is inhibited by glucose. Phosphoprotein phosphatase catalyzes the attachment of a phosphate group to a Ser residue in glycogen phosphorylase. The allosteric modulator glucose-6-phosphate promotes the conformation change from inactive T state to active R state.
What is meant by reciprocal regulation ? Name one compound that reciprocally regulates glycolysis and gluconeogenesis pathways . Which enzymes are regulated by this compound? What reactions are catalyzed by these enzymes (structures not required) ?
Help me understand this…I’m confused
The first step of gluconeogenesis involves the carboxylation of pyruvate and has a large negative delta G (i.e very exergonic). Explain how it is possible that this step can be exergonic if we know that adding CO2 onto molecules is fundamentally a destabilizing phenomenon?
In the skeletal muscle, in anaerobic conditions, glyceraldehyde 3-phosphate is converted into pyruvate during the payoff phase of glycolysis; and this pyruvate is reduced into lactate during lactic fermentation. Part 1-Write the 11 balanced biochemical equations corresponding to all the reaction steps leading to the conversion of glyceraldehyde-3-phosphate into lactate through glycolysis followed by lactic fermentation. Part 2-Write the net equation of the whole transformation process (i.e. with glyceraldehyde-3-phosphate as the starting substrate; and lactate as the end product).
Which of the following statements are True as to the location in pyruvate of labeled carbons if glucose molecules labeled (in separate experiments) with 14C (radioactive carbon) at each position of the carbon skeleton proceed through the Glycolytic pathway. Multiple answers:Multiple answers are accepted for this question a The carboxyl carbon of pyruvate derives from carbon 3 of glucose. b The keto carbon of pyruvate derives from carbon 2 of glucose. c The methyl carbon of pyruvate derives from carbon 1 of glucose. d The carboxyl carbon of pyruvate derives from carbon 4 of glucose. e The keto carbon of pyruvate derives from carbon 5 of glucose. f The methyl carbon of pyruvate derives from carbon 6 of glucose. g The carboxyl carbon of pyruvate derives from carbon 2 of glucose. h The keto carbon of pyruvate derives from carbon 3 of glucose. i The methyl carbon of pyruvate derives from carbon 4 of glucose.
Back in 1962, Gerhart and Pardee developed a model for the regulation of the activity of the ATCase enzyme by CTP and ATP, using the pathway given in Figure 1. Describe that model, using information presented here as well as what you have learned about allosteric enzymes. Be sure to include a sentence explaining the physiological significance of your model.
The AG of the reaction C6H12O6 + 60₂ --> 6CO₂ + 6H₂O is -686 kcal/mol glucose oxidized. The AG of the reaction ADP + P₁ --> ATP + H₂O is + 7.3 kcal/mol ATP synthesized. The oxidation of glucose can be coupled to the synthesis of ATP. If the coupling is 50% efficient, how many molecules of ATP can be synthesized per molecule of glucose oxidized? Round your answer to the nearest whole number.

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Step 3: the phosphorylation of fructose 6-phosphate, is the first committed step of glycolysis. This step is catalyzed by phosphofructokinase, an enzyme that can be regulated allosterically by many molecules (two of which are ADP and phosphoenolpyruvate). Why is this regulation important?