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(-)-Spongidepsin is a marine natural product that is toxic to some cancer cells. During a synthesis of (-)-spongidepsin, compound converted into compound 2. (Org. Lett. 2010, 12, 4392-4395.) Propose a synthesis for the conversion of 1 into 2. OPMB OH PMB= OCH OPMB OH (-)-Spongidepsin The transformation above can be performed with some reagent or combination of the reagents listed below. Give the necessary reagents in the correct order, as a string of letters (without spaces or punctuation, such as "EBF"). If there is more than one correct solution, provide just one answer. efl a) H*, 요 e) PCC, CH2Cl2 i) RCO3H b) 1) 21 HO MgBr f) 1) MeMgBr; 2) H3O+ j) BH3 THF, H2O2, NaOH

(-)-Spongidepsin is a marine natural product that is toxic to some cancer cells. During a synthesis of (-)-spongidepsin, compound converted into compound 2. (Org. Lett. 2010, 12, 4392-4395.) Propose a synthesis for the conversion of 1 into 2. OPMB OH PMB= OCH OPMB OH (-)-Spongidepsin The transformation above can be performed with some reagent or combination of the reagents listed below. Give the necessary reagents in the correct order, as a string of letters (without spaces or punctuation, such as "EBF"). If there is more than one correct solution, provide just one answer. efl a) H*, 요 e) PCC, CH2Cl2 i) RCO3H b) 1) 21 HO MgBr f) 1) MeMgBr; 2) H3O+ j) BH3 THF, H2O2, NaOH

Chemistry
Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
Section: Chapter Questions
Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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(-)-Spongidepsin is a marine natural product that is toxic to some cancer cells. During a synthesis of (-)-spongidepsin, compound converted into compound 2. (Org. Lett. 2010, 12, 4392-4395.) Propose a synthesis for the conversion of 1 into 2. OPMB OH PMB= OCH OPMB OH (-)-Spongidepsin The transformation above can be performed with some reagent or combination of the reagents listed below. Give the necessary reagents in the correct order, as a string of letters (without spaces or punctuation, such as "EBF"). If there is more than one correct solution, provide just one answer. efl a) H*, 요 e) PCC, CH2Cl2 i) RCO3H b) 1) 21 HO MgBr f) 1) MeMgBr; 2) H3O+ j) BH3 THF, H2O2, NaOH
Transcribed Image Text:(-)-Spongidepsin is a marine natural product that is toxic to some cancer cells. During a synthesis of (-)-spongidepsin, compound converted into compound 2. (Org. Lett. 2010, 12, 4392-4395.) Propose a synthesis for the conversion of 1 into 2. OPMB OH PMB= OCH OPMB OH (-)-Spongidepsin The transformation above can be performed with some reagent or combination of the reagents listed below. Give the necessary reagents in the correct order, as a string of letters (without spaces or punctuation, such as "EBF"). If there is more than one correct solution, provide just one answer. efl a) H*, 요 e) PCC, CH2Cl2 i) RCO3H b) 1) 21 HO MgBr f) 1) MeMgBr; 2) H3O+ j) BH3 THF, H2O2, NaOH
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