но NH OH A H. Ergotamine Lysergic acid diethylamide of

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Reagents and mechanism please 

This is a reaction pathway depicting the synthesis of Lysergic acid diethylamide (LSD) from Ergotamine.

1. **Ergotamine Structure:**
   - The chemical structure on the far left is Ergotamine, a complex molecule containing a bicyclic hexahydroindole ring system fused with a lysergic acid moiety.

2. **Transformation A:**
   - The first arrow labeled "A" indicates the initial transformation where Ergotamine undergoes a reaction to form an intermediary compound. This involves modifying the side chain while retaining the indole and hexahydroindole ring systems.

3. **Transformation B:**
   - The second arrow labeled "B" represents the conversion of the intermediate compound to another structure, showing the replacement of a hydroxyl group with a chlorine atom, and the retention of the core bicyclic structure.

4. **Transformation C:**
   - The final step, labeled "C", involves the transformation to Lysergic acid diethylamide (LSD), characterized by the addition of a diethylamide group.

5. **Lysergic Acid Diethylamide (LSD) Structure:**
   - The final structure on the far right is LSD, featuring a core lysergic acid structure with a diethylamide functional group.

This pathway illustrates the transformation of a natural compound into a synthetic derivative via a series of chemical reactions. It emphasizes synthetic organic chemistry techniques applied to medicinal chemistry.
Transcribed Image Text:This is a reaction pathway depicting the synthesis of Lysergic acid diethylamide (LSD) from Ergotamine. 1. **Ergotamine Structure:** - The chemical structure on the far left is Ergotamine, a complex molecule containing a bicyclic hexahydroindole ring system fused with a lysergic acid moiety. 2. **Transformation A:** - The first arrow labeled "A" indicates the initial transformation where Ergotamine undergoes a reaction to form an intermediary compound. This involves modifying the side chain while retaining the indole and hexahydroindole ring systems. 3. **Transformation B:** - The second arrow labeled "B" represents the conversion of the intermediate compound to another structure, showing the replacement of a hydroxyl group with a chlorine atom, and the retention of the core bicyclic structure. 4. **Transformation C:** - The final step, labeled "C", involves the transformation to Lysergic acid diethylamide (LSD), characterized by the addition of a diethylamide group. 5. **Lysergic Acid Diethylamide (LSD) Structure:** - The final structure on the far right is LSD, featuring a core lysergic acid structure with a diethylamide functional group. This pathway illustrates the transformation of a natural compound into a synthetic derivative via a series of chemical reactions. It emphasizes synthetic organic chemistry techniques applied to medicinal chemistry.
**Question 35**

Ergotamine, an alkaloid isolated from a fungus that infects rye, is used medicinally for the treatment of acute migraine attacks (sometimes in combination with caffeine). It is a controlled substance in the United States as it is a commonly used precursor for the production of lysergic acid diethylamide (LSD).

Look at the synthetic pathway below. 

[Note: There is no diagram or graph present in the image above.]
Transcribed Image Text:**Question 35** Ergotamine, an alkaloid isolated from a fungus that infects rye, is used medicinally for the treatment of acute migraine attacks (sometimes in combination with caffeine). It is a controlled substance in the United States as it is a commonly used precursor for the production of lysergic acid diethylamide (LSD). Look at the synthetic pathway below. [Note: There is no diagram or graph present in the image above.]
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