Select the hemoglobin variant(s) that are described by each statement.(a) The variant least likely to cause pathological symptoms.(b) The variant(s) likely to show pl values different from that of HbA on an isoelectricfocusing gel.(c) The variant most likely to show a decrease in BPG binding and an increase inthe overall affinity of the hemoglobin for oxygen.Answer BankHb MilwaukeeHb CowtownHb MemphisHb PhillyHb ProvidenceHb BibbaHbS

Haemoglobin is a subunit protein that binds to oxygen and supplies oxygen to the different parts of…

Answered: Select the hemoglobin variant(s) that…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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Similar questions

Fetal hemoglobin comprises of αγ sub-units. It has been found that the γ-chain contains serine at position 143 instead of Histidine 143 normally found in the β-chain. The amino acid 143 lines the DPG binding site. This mutation in the γ chain results in a) Increased Oxygen binding in the fetus. b) Increased efficiency of oxygen transport to the lungs in the fetus. c) Increased DPG binding in the fetal hemoglobin d) This is a silent mutation, i.e. no change should be observed.
Explain ONE suitable additional test the lab in London might use to determine the haemoglobin proteins present in Ema’s cell lysate. Explain the result that would support your most likely diagnosis.
23 A 9-month-old infant is found have severe iron-deficiency anemia at a routine examination. An increase in which of the following laboratory values is most consistent with this diagnosis? A) Free erythrocyte protoporphyrin concentration OB) Serum direct bilirubin concentration C) Serum ferritin concentration D) Serum indirect bilirubin concentration OE) Transferrin saturation
Can all abnormal hemoglobin be diagnosed by electrophoresis? Explain your answer in detail.
The basic principle of the fibrinogen test is most similar to which other test? Question 6 options: A) thrombin time B) prothrombin time C) activated partial thromboplastin time D) bleeding time
Which of the following concerning hemoglobin is true? a) BPG decreases at high altitudes and causes more O2 offloading in tissues b) As pH increases, [CO2] increases in tissues, causing more O2 release in tissue c) The R state is stabilized by CO2 binding, whereas the T state is stabilized by O2 binding d) About 38% of oxygen dissociates from hemoglobin in tissues e) Hemoglobin has a higher affinity for oxygen than carbon monoxide My guess is D.
37. Binding of thrombin to which of the following molecules converts it from a procoagulant to an anticoagulant? A) Factor V (proaccelerin) B) Factor VIII (antihemophilic factor) C) Fibrinogen D) Thrombomodulin E) von Willebrand factor
A patient is receiving dabigatran (Pradaxa), 150 mg t-ice daily, as part of treatment for atrial fibrillation. Which condition, if present, -ould be a concern if the patient -ere to receive this dose? a) Asthmab )Renal impairmentc )History of myocardial infarctiond )Elevated liver enzymes
What would be the consequence of a deficiency of hemoglobin in our bodies?
What is suspected when the hematocrit has decreased by 4% and the total bilirubin level is increased 5 days after transfusion? Question 8 options: a) Urticarial reaction b) Volume overload c) Delayed hemolytic transfusion reaction d) Acute hemolytic transfusion reaction
In hemoglobin from patients with sickle cell anemia, the hemoglobin ß-chains have a single amino substitution that results in: A) A sticky spot in the hemoglobin causing polymerization O B) A change in the oxygen binding to hemoglobin that causes formation of polymers C) Changes in the interaction between B-chains and x-chains OD) Changes in binding of 2,3-bisphosphoglycerate
Which of the following is a sensitive indicator of early inon deficiency(). A) serum iron B) Transferrin saturation C) serum ferritin D) Erythrocyte free protoporphyrin E) Bone marrow can be stained with iron

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