[References] The peptide aspartame, shown in the sketch drawing window, has several ionizable groups. Adjust the charges to show the molecule as it would exist at pH 7.00. Use the pk, values in the table below. pK, Values for Ionizable Groups of Amino Acids. Amino Acid pK, of a-COOH pK, of a-NH pK, of Side Chain Isoelectric Point (pl) 6.11 Alanine 2.35 9.87 9.04 12.48 10.76 Arginine 2.01 8.80 5.41 Asparagine 2.02 9.82 3.86 2.98 Aspartic acid 2.10 10.25 8.00 5.02 Cysteine 2.05 9.47 4.07 3.08 Glutamic acid 2.10 5.65 Glutamine 2.17 9.13 6.06 Glycine 2.35 9.78 6.10 7.64 Histidine 7.11 9.18 6.04 Isoleucine 2.32 9.76 6.04 Leucine 2.33 9.74 10.53 9.74 Lysine 2.18 8.95 5.74 Methionine 2.28 9.21 5.91 9.24 Phenylalanine 2.58 6.30 Proline 2.00 10.60 5.68 Serine 2.21 9.15 Previous Next 5.60 Threonine 2.09 9.10 5.88 Tryptophan 2.38 9.39 Uprtructor Save a
[References] The peptide aspartame, shown in the sketch drawing window, has several ionizable groups. Adjust the charges to show the molecule as it would exist at pH 7.00. Use the pk, values in the table below. pK, Values for Ionizable Groups of Amino Acids. Amino Acid pK, of a-COOH pK, of a-NH pK, of Side Chain Isoelectric Point (pl) 6.11 Alanine 2.35 9.87 9.04 12.48 10.76 Arginine 2.01 8.80 5.41 Asparagine 2.02 9.82 3.86 2.98 Aspartic acid 2.10 10.25 8.00 5.02 Cysteine 2.05 9.47 4.07 3.08 Glutamic acid 2.10 5.65 Glutamine 2.17 9.13 6.06 Glycine 2.35 9.78 6.10 7.64 Histidine 7.11 9.18 6.04 Isoleucine 2.32 9.76 6.04 Leucine 2.33 9.74 10.53 9.74 Lysine 2.18 8.95 5.74 Methionine 2.28 9.21 5.91 9.24 Phenylalanine 2.58 6.30 Proline 2.00 10.60 5.68 Serine 2.21 9.15 Previous Next 5.60 Threonine 2.09 9.10 5.88 Tryptophan 2.38 9.39 Uprtructor Save a
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
Related questions
Question
The peptide aspartame, has several ionizable groups. Adjust the charges to show the molecule as it would exist at pH 7.00. Use the pka values in the table below.
![enow.com/
[References]
The peptide aspartame, shown in the sketch drawing window, has several ionizable groups. Adjust the charges to show the molecule as it would exist at pH 7.00. Use the pK, values in the table
below.
pK, Values for Ionizable Groups of Amino Acids.
Amino Acid
pK, of a-COOH pK, of a-NH pK, of Side Chain Isoelectric Point (pI)
9.87
6.11
Alanine
2.35
9.04
12.48
10.76
Arginine
2.01
5.41
Asparagine
2.02
8.80
3.86
2.98
Aspartic acid
2.10
9.82
10.25
8.00
5.02
Cysteine
2.05
Glutamic acid 2.10
9.47
4.07
3.08
5.65
Glutamine
2.17
9.13
6.06
Glycine
2.35
9.78
6.10
7.64
Histidine
7.11
9.18
6.04
Isoleucine
2.32
9.76
6.04
Leucine
2.33
9.74
10.53
9.74
Lysine
2.18
8.95
5.74
Methionine
2.28
9.21
5.91
9.24
Phenylalanine 2.58
6.30
Proline
2.00
10.60
5.68
Serine
2.21
9.15
Previous
Next
5.60
Threonine
2.09
9.10
5.88
Trvntophan
2.38
9.39
Email Instructor
Save an](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2F41e88f98-3959-4be4-9528-9cf33ab21844%2Fc44b7f9d-b7a2-4084-9ee6-258032b1239e%2F35tl2xw_processed.jpeg&w=3840&q=75)
Transcribed Image Text:enow.com/
[References]
The peptide aspartame, shown in the sketch drawing window, has several ionizable groups. Adjust the charges to show the molecule as it would exist at pH 7.00. Use the pK, values in the table
below.
pK, Values for Ionizable Groups of Amino Acids.
Amino Acid
pK, of a-COOH pK, of a-NH pK, of Side Chain Isoelectric Point (pI)
9.87
6.11
Alanine
2.35
9.04
12.48
10.76
Arginine
2.01
5.41
Asparagine
2.02
8.80
3.86
2.98
Aspartic acid
2.10
9.82
10.25
8.00
5.02
Cysteine
2.05
Glutamic acid 2.10
9.47
4.07
3.08
5.65
Glutamine
2.17
9.13
6.06
Glycine
2.35
9.78
6.10
7.64
Histidine
7.11
9.18
6.04
Isoleucine
2.32
9.76
6.04
Leucine
2.33
9.74
10.53
9.74
Lysine
2.18
8.95
5.74
Methionine
2.28
9.21
5.91
9.24
Phenylalanine 2.58
6.30
Proline
2.00
10.60
5.68
Serine
2.21
9.15
Previous
Next
5.60
Threonine
2.09
9.10
5.88
Trvntophan
2.38
9.39
Email Instructor
Save an
Transcribed Image Text:P
opy
aste
[片
NH,
H&C,
HO
ChemDoodle
== starting points
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