Quit Smoking: The New England Journal of Medicine published the results of a double-blind, placebo-controlled experiment to study the effect of nicotine patches and the antidepressant bupropion on quitting smoking. The target for quitting smoking was the 8th day of the experiment. In this experiment researchers randomly assigned smokers to treatments. The following is an excerpt from this same study. “ A total of 311 subjects (34.8 percent) discontinued one or both medications. Seventy-nine subjects stopped treatment because of adverse events: 6 in the placebo group (3.8 percent), 16 in the nicotine-patch group (6.6 percent), 29 in the bupropion group (11.9 percent), and 28 in the combined treatment group (11.4 percent). The most common adverse events were insomnia and headache.” Recall that 160 smokers took the placebo and 244 smokers used nicotine patches. Could the researcher use this data with an inference procedure from this module to test a claim about (or to estimate the difference in) side effects from a placebo compared to nicotine patches? Yes, because subjects were randomly assigned to treatment groups Yes, the percentages of side effects are large enough to see a difference No, the conditions for use of a normal model for the sampling distribution of sample differences is not met No, the experiment did not randomly assign side-effects to subjects

MATLAB: An Introduction with Applications

6th Edition

ISBN:9781119256830

Author:Amos Gilat

Publisher:Amos Gilat

Chapter1: Starting With Matlab

Section: Chapter Questions

Problem 1P

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Quit Smoking: The New England Journal of Medicine published the results of a double-blind, placebo-controlled experiment to study the effect of nicotine patches and the antidepressant bupropion on quitting smoking. The target for quitting smoking was the 8th day of the experiment. In this experiment researchers randomly assigned smokers to treatments.

The following is an excerpt from this same study. “ A total of 311 subjects (34.8 percent) discontinued one or both medications. Seventy-nine subjects stopped treatment because of adverse events: 6 in the placebo group (3.8 percent), 16 in the nicotine-patch group (6.6 percent), 29 in the bupropion group (11.9 percent), and 28 in the combined treatment group (11.4 percent). The most common adverse events were insomnia and headache.” Recall that 160 smokers took the placebo and 244 smokers used nicotine patches.

Could the researcher use this data with an inference procedure from this module to test a claim about (or to estimate the difference in) side effects from a placebo compared to nicotine patches?

Yes, because subjects were randomly assigned to treatment groups
Yes, the percentages of side effects are large enough to see a difference
No, the conditions for use of a normal model for the sampling distribution of sample differences is not met
No, the experiment did not randomly assign side-effects to subjects

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