Question 6 a) Show using mechanism arrows how the anomeric centre in glucose inverts when it is dissolved in water. Be sure to draw any intermediates in your answer. HO- HO- OH Glucose b) Briefly explain using words and/or structures why reducing sugars are not suitable for use in tablets and solutions with some amine containing drugs. c) (S)-glutamic acid has 3 pk, values as illustrated on the diagram below. Calculate the isoelectric point of this amino acid. You must show your working. pk 10.01 NH₂ HO OH pk 4.01 pk, 2.19 Glutamic acid derivative d) Draw the most abundant ion of the glutamic acid derivative at pH 7.0, showing all charges. HO. OH

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Chapter1: Chemical Foundations
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Question 6
a) Show using mechanism arrows how the anomeric centre in glucose inverts when it is dissolved in water. Be sure to draw any
intermediates in your answer.
HO-
HO-
OH
Glucose
b) Briefly explain using words and/or structures why reducing sugars are not suitable for use in tablets and solutions with some amine
containing drugs.
c) (S)-glutamic acid has 3 pk, values as illustrated on the diagram below. Calculate the isoelectric point of this amino acid. You must
show your working.
pk 10.01
NH₂
HO
OH
pk 4.01
pk, 2.19
Glutamic acid derivative
d) Draw the most abundant ion of the glutamic acid derivative at pH 7.0, showing all charges.
HO.
OH
Transcribed Image Text:Question 6 a) Show using mechanism arrows how the anomeric centre in glucose inverts when it is dissolved in water. Be sure to draw any intermediates in your answer. HO- HO- OH Glucose b) Briefly explain using words and/or structures why reducing sugars are not suitable for use in tablets and solutions with some amine containing drugs. c) (S)-glutamic acid has 3 pk, values as illustrated on the diagram below. Calculate the isoelectric point of this amino acid. You must show your working. pk 10.01 NH₂ HO OH pk 4.01 pk, 2.19 Glutamic acid derivative d) Draw the most abundant ion of the glutamic acid derivative at pH 7.0, showing all charges. HO. OH
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