Question 5. The biosynthesis of fatty acids involves an enzyme-catalyzed hydrogenation of an a,ß-unsaturated thioester to the saturated fatty acid intermediate mediated by NADPH+. However, the reverse oxidation reaction during fatty acid metabolism requires a different cofactor FAD. Fatty Acid Biosynthesis a) Draw the structure of FAD. H flocon SCOA H SR + FAD - FADH₂ hydrogenation (reduction) NADPH+, H+ dehydrogenation (oxidation) FAD Fatty Acid Metabolism b) Draw a detailed mechanism of the dehydrogenation of fatty acyl-CoA by FAD (you can abbreviate AD as R). H SR

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Question 5.
The biosynthesis of fatty acids involves an enzyme-catalyzed hydrogenation of an
a,ß-unsaturated thioester to the saturated fatty acid intermediate mediated by
NADPH+. However, the reverse oxidation reaction during fatty acid metabolism
requires a different cofactor FAD.
Fatty Acid
Biosynthesis
a) Draw the structure of FAD.
H
flocon
SCOA
H
SR
+ FAD
- FADH₂
hydrogenation
(reduction)
NADPH+, H+
dehydrogenation
(oxidation)
FAD
Fatty Acid
Metabolism
b) Draw a detailed mechanism of the dehydrogenation of fatty acyl-CoA by FAD
(you can abbreviate AD as R).
H
SR
Transcribed Image Text:Question 5. The biosynthesis of fatty acids involves an enzyme-catalyzed hydrogenation of an a,ß-unsaturated thioester to the saturated fatty acid intermediate mediated by NADPH+. However, the reverse oxidation reaction during fatty acid metabolism requires a different cofactor FAD. Fatty Acid Biosynthesis a) Draw the structure of FAD. H flocon SCOA H SR + FAD - FADH₂ hydrogenation (reduction) NADPH+, H+ dehydrogenation (oxidation) FAD Fatty Acid Metabolism b) Draw a detailed mechanism of the dehydrogenation of fatty acyl-CoA by FAD (you can abbreviate AD as R). H SR
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