Question 4: Tropomyosin is a 93 kDa protein which sediments at 2.6S (the sedimentation coefficient S is a linear measure of the rate of sedimentation during centrifugation). Hemogloblin is a smaller protein (63 kDa), but it sediments faster at 4.3S. The two proteins are drawn to scale in the figure below. Using this information, explain why the larger protein (tropomyosin) sediments more slowly than the smaller protein (hemogloblin). How would this change if you treated both proteins with SDS and B-mercaptoethanol prior to sedimentation via centrifugation?
Question 4: Tropomyosin is a 93 kDa protein which sediments at 2.6S (the sedimentation coefficient S is a linear measure of the rate of sedimentation during centrifugation). Hemogloblin is a smaller protein (63 kDa), but it sediments faster at 4.3S. The two proteins are drawn to scale in the figure below. Using this information, explain why the larger protein (tropomyosin) sediments more slowly than the smaller protein (hemogloblin). How would this change if you treated both proteins with SDS and B-mercaptoethanol prior to sedimentation via centrifugation?
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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Question 4: Tropomyosin is a 93 kDa protein which sediments at 2.6S (the sedimentation coefficient S
is a linear measure of the rate of sedimentation during centrifugation). Hemogloblin is a smaller
protein (63 kDa), but it sediments faster at 4.3S. The two proteins are drawn to scale in the figure
below. Using this information, explain why the larger protein (tropomyosin) sediments more slowly
than the smaller protein (hemogloblin). How would this change if you treated both proteins with SDS
and B-mercaptoethanol prior to sedimentation via centrifugation?
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