Question 3 A 50 kDa protein has a minimum radius 2.4nm, while a 20 kDa protein has a minimum radius of 1.78 nm. Based on this, which of the following is likely true of the nuclear pore complex? mRNA (2 x 300 nm) would be able to pass freely through the pore a protein with a radius of 1.5 nm would require a NLS for transport into the nucleus the NPC would not allow proteins with a radius >2.5 nm to pass through freely, regardless of the protein's concentration the NPC allows proteins with a radius <1.78 nm to pass freely, and movement is dependent only on the protein's concentration gradient

Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
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Question 3
A 50 kDa protein has a minimum radius 2.4nm, while a 20 kDa protein has a minimum radius of 1.78 nm. Based on this, which of the
following is likely true of the nuclear pore complex?
mRNA (2 x 300 nm) would be able to pass freely through the pore
a protein with a radius of 1.5 nm would require a NLS for transport into the nucleus
the NPC would not allow proteins with a radius >2.5 nm to pass through freely, regardless of the protein's concentration
the NPC allows proteins with a radius <1.78 nm to pass freely, and movement is dependent only on the protein's concentration
gradient
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<10 KDa : passively controlled by concentration
10-40 KDa : passive but regulated by calcium
>40 kDa: requires active transport via importin/exportin
Transcribed Image Text:Question 3 A 50 kDa protein has a minimum radius 2.4nm, while a 20 kDa protein has a minimum radius of 1.78 nm. Based on this, which of the following is likely true of the nuclear pore complex? mRNA (2 x 300 nm) would be able to pass freely through the pore a protein with a radius of 1.5 nm would require a NLS for transport into the nucleus the NPC would not allow proteins with a radius >2.5 nm to pass through freely, regardless of the protein's concentration the NPC allows proteins with a radius <1.78 nm to pass freely, and movement is dependent only on the protein's concentration gradient Hide Feedback for Question 3 <10 KDa : passively controlled by concentration 10-40 KDa : passive but regulated by calcium >40 kDa: requires active transport via importin/exportin
Question 4
If a cell had an over-expression of importin, it could result in increased import of proteins into the nucleus, but only if there was also
a large enough supply of Ran-GTP in the nucleoplasm.
True
False
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Ran-GTP is required for the cargo protein to be released in the nucleoplasm, and for importin to recycle back to the cytoplasm.
Transcribed Image Text:Question 4 If a cell had an over-expression of importin, it could result in increased import of proteins into the nucleus, but only if there was also a large enough supply of Ran-GTP in the nucleoplasm. True False Hide Feedback for Question 4 Ran-GTP is required for the cargo protein to be released in the nucleoplasm, and for importin to recycle back to the cytoplasm.
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