Question 3 A 50 kDa protein has a minimum radius 2.4nm, while a 20 kDa protein has a minimum radius of 1.78 nm. Based on this, which of the following is likely true of the nuclear pore complex? mRNA (2 x 300 nm) would be able to pass freely through the pore a protein with a radius of 1.5 nm would require a NLS for transport into the nucleus the NPC would not allow proteins with a radius >2.5 nm to pass through freely, regardless of the protein's concentration the NPC allows proteins with a radius <1.78 nm to pass freely, and movement is dependent only on the protein's concentration gradient

Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
icon
Related questions
Question
Question 3
A 50 kDa protein has a minimum radius 2.4nm, while a 20 kDa protein has a minimum radius of 1.78 nm. Based on this, which of the
following is likely true of the nuclear pore complex?
mRNA (2 x 300 nm) would be able to pass freely through the pore
a protein with a radius of 1.5 nm would require a NLS for transport into the nucleus
the NPC would not allow proteins with a radius >2.5 nm to pass through freely, regardless of the protein's concentration
the NPC allows proteins with a radius <1.78 nm to pass freely, and movement is dependent only on the protein's concentration
gradient
Hide Feedback for Question 3
<10 KDa : passively controlled by concentration
10-40 KDa : passive but regulated by calcium
>40 kDa: requires active transport via importin/exportin
Transcribed Image Text:Question 3 A 50 kDa protein has a minimum radius 2.4nm, while a 20 kDa protein has a minimum radius of 1.78 nm. Based on this, which of the following is likely true of the nuclear pore complex? mRNA (2 x 300 nm) would be able to pass freely through the pore a protein with a radius of 1.5 nm would require a NLS for transport into the nucleus the NPC would not allow proteins with a radius >2.5 nm to pass through freely, regardless of the protein's concentration the NPC allows proteins with a radius <1.78 nm to pass freely, and movement is dependent only on the protein's concentration gradient Hide Feedback for Question 3 <10 KDa : passively controlled by concentration 10-40 KDa : passive but regulated by calcium >40 kDa: requires active transport via importin/exportin
Question 4
If a cell had an over-expression of importin, it could result in increased import of proteins into the nucleus, but only if there was also
a large enough supply of Ran-GTP in the nucleoplasm.
True
False
Hide Feedback for Question 4
Ran-GTP is required for the cargo protein to be released in the nucleoplasm, and for importin to recycle back to the cytoplasm.
Transcribed Image Text:Question 4 If a cell had an over-expression of importin, it could result in increased import of proteins into the nucleus, but only if there was also a large enough supply of Ran-GTP in the nucleoplasm. True False Hide Feedback for Question 4 Ran-GTP is required for the cargo protein to be released in the nucleoplasm, and for importin to recycle back to the cytoplasm.
Expert Solution
trending now

Trending now

This is a popular solution!

steps

Step by step

Solved in 2 steps

Blurred answer
Similar questions
  • SEE MORE QUESTIONS
Recommended textbooks for you
Biochemistry
Biochemistry
Biochemistry
ISBN:
9781319114671
Author:
Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:
W. H. Freeman
Lehninger Principles of Biochemistry
Lehninger Principles of Biochemistry
Biochemistry
ISBN:
9781464126116
Author:
David L. Nelson, Michael M. Cox
Publisher:
W. H. Freeman
Fundamentals of Biochemistry: Life at the Molecul…
Fundamentals of Biochemistry: Life at the Molecul…
Biochemistry
ISBN:
9781118918401
Author:
Donald Voet, Judith G. Voet, Charlotte W. Pratt
Publisher:
WILEY
Biochemistry
Biochemistry
Biochemistry
ISBN:
9781305961135
Author:
Mary K. Campbell, Shawn O. Farrell, Owen M. McDougal
Publisher:
Cengage Learning
Biochemistry
Biochemistry
Biochemistry
ISBN:
9781305577206
Author:
Reginald H. Garrett, Charles M. Grisham
Publisher:
Cengage Learning
Fundamentals of General, Organic, and Biological …
Fundamentals of General, Organic, and Biological …
Biochemistry
ISBN:
9780134015187
Author:
John E. McMurry, David S. Ballantine, Carl A. Hoeger, Virginia E. Peterson
Publisher:
PEARSON