QUESTION 18 Stable molecules that resemble the transition state of enzyme catalyzed reactions are very potent inhibitors. Provide an explanation as to why these compounds are better than inhibitors based on the substrate.

QUESTION 18 Stable molecules that resemble the transition state of enzyme catalyzed reactions are very potent inhibitors. Provide an explanation as to why these compounds are better than inhibitors based on the substrate.

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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Nitrogen metabolism

Nitrogen metabolism is the synthesis, utilization or uptake, breakdown, and excretion of nitrogenous compounds in the body. The nitrogen metabolism encompasses nitrogen fixation, biosynthesis, and the breakdown of amino acids, purines, and pyrimidine. Since nitrogen-containing compounds are required for various life processes, nitrogen is an important element of life.

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